Institute of Gerontology, Jönköping University, Jönköping, Sweden.
Acta Neurol Scand. 2010 Oct;122(4):286-94. doi: 10.1111/j.1600-0404.2009.01310.x. Epub 2009 Dec 28.
To investigate whether there is a relationship between the clinical occurrence of migraine and biliary tract disorders (BTD) and to study whether there is a genetic influence on such an association.
The near lifetime morbidity for migraine and BTD was examined in two Swedish twin-samples: OCTO-Twin (149 MZ and 202 DZ pairs; 234 men, 468 women; 80 years of age or older at inclusion), and the GENDER study (249 unlike-sex DZ-pairs; 70-80 years of age at inclusion). The diagnosis of BTD was established by perusal of medical records from the last twenty years. The diagnosis of migraine was based on iterated questionnaires and personal interviews.
The odds ratio (OR) of BTD among OCTO-Twin subjects suffering from migraine was 3.5 (1.9-6.7) in monozygotic pairs and 1.7 (1.0-2.9) in dizygotic pairs The corresponding figures among the GENDER unlike-sex DZ-pairs was 2.7 (1.6-4.5). Migraine was associated with female sex and waist circumference.
There is a relationship between the occurrence of migraine and BTD, also when controlling for the fact that both disorders are more frequent in women. The association appears to be partly attributable to genetic influences.
研究偏头痛的临床发作与胆道疾病（BTD）之间是否存在关系，并探讨这种关联是否存在遗传影响。
在两个瑞典双胞胎样本中检查了偏头痛和 BTD 的终身近发病率：OCTO-Twin（149 对 MZ 和 202 对 DZ，234 名男性，468 名女性；纳入时年龄在 80 岁或以上）和 GENDER 研究（249 对不同性别 DZ 对；纳入时年龄在 70-80 岁之间）。通过查阅过去 20 年的医疗记录来确定 BTD 的诊断。偏头痛的诊断基于反复的问卷和个人访谈。
在 OCTO-Twin 偏头痛患者中，BTD 的比值比（OR）在同卵双胞胎中为 3.5（1.9-6.7），在异卵双胞胎中为 1.7（1.0-2.9）。在 GENDER 不同性别 DZ 对中，相应的数字为 2.7（1.6-4.5）。偏头痛与女性性别和腰围有关。
偏头痛的发生与 BTD 之间存在关系，即使在考虑到这两种疾病在女性中更为常见的情况下也是如此。这种关联似乎部分归因于遗传影响。
