渴望消除炎症？血清素与肿瘤坏死因子信号传导之间的新联系。
Wishing away inflammation? New links between serotonin and TNF signaling.
作者信息
Pelletier Martin, Siegel Richard M
机构信息
Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD 20814, USA.
出版信息
Mol Interv. 2009 Dec;9(6):299-301. doi: 10.1124/mi.9.6.5.
Abstract
Although the influence of neural activity on immune and inflammatory pathways is undisputed, details of how neurotransmitters modulate signaling by cytokine and antigen receptors remain sketchy. New findings on the influence of the serotonin receptor subtype 2A (5-HT2A) and receptors for Tumor Necrosis Factor (TNF) suggest that in some cases there may be direct interactions between neurotransmitter and cytokine receptor signaling. These findings have implications for the many psychiatric patients on medications that modulate serotonin signaling and suggest that neurotransmitter receptors should not be ignored as candidate targets for immunoregulation.
摘要
尽管神经活动对免疫和炎症通路的影响是毋庸置疑的，但神经递质如何调节细胞因子和抗原受体的信号传导细节仍不明确。关于血清素受体亚型2A（5-HT2A）和肿瘤坏死因子（TNF）受体影响的新发现表明，在某些情况下，神经递质和细胞因子受体信号传导之间可能存在直接相互作用。这些发现对许多服用调节血清素信号传导药物的精神病患者具有启示意义，并表明神经递质受体作为免疫调节的候选靶点不应被忽视。
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