Institut für Transplantationsdiagnostik und Zelltherapeutika, José Carreras Stammzellbank, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
Dtsch Arztebl Int. 2009 Dec;106(50):831-6. doi: 10.3238/arztebl.2009.0831. Epub 2009 Dec 11.
Physicians of any specialty may be the first persons to whom prospective parents turn for information about the acquisition and storage of stem cells derived from cord blood. Stem cells can potentially be used to treat many diseases, yet they are not a panacea. This article provides an overview of their current and possible future applications.
Original papers were retrieved by a selective search of the literature, and the Internet sites and advertising brochures of private stem cell banks were also examined.
Allogeneic hematopoietic stem cells derived from umbilical cord blood (obtained from healthy donors, rather than from the patient to be treated) have been in routine use worldwide for more than ten years in the treatment of hematopoietic diseases. Experiments in cell culture and in animal models suggest that these cells might be of therapeutic use in regenerative medicine, but also show that this potential can be realized only if the cells are not cryopreserved. There is as yet no routine clinical application of autologous hematopoietic stem cells from cord blood (self-donation of blood), even though cord blood has been stored in private banks for more than ten years.
Autologous stem cells from cord blood have poor prospects for use in regenerative medicine, because they have to be cryopreserved until use. Physicians should tell prospective parents that they have no reason to feel guilty if they choose not to store cord blood in a private bank.
任何专业的医生都可能是准父母们首先寻求有关获取和储存脐带血衍生干细胞信息的人。干细胞具有治疗许多疾病的潜力，但并非万无一失。本文概述了它们目前和未来可能的应用。
通过对文献的选择性搜索，检索了原始论文，并检查了私人干细胞库的互联网网站和广告手册。
异体造血干细胞来源于脐带血（从健康供体中获得，而不是从要治疗的患者中获得），在全球范围内已常规使用十余年，用于治疗血液疾病。细胞培养和动物模型实验表明，这些细胞在再生医学中可能具有治疗用途，但也表明只有在不冷冻保存细胞的情况下，才能实现这种潜力。尽管已经将脐带血在私人银行中储存了十余年，但尚未常规应用自体造血干细胞（自采血）。
脐带血中的自体干细胞在再生医学中的应用前景不佳，因为它们必须冷冻保存，直到使用为止。医生应该告诉准父母，如果他们选择不在私人银行中储存脐带血，他们没有理由感到内疚。
