Department of Psychology, University of Helsinki, Helsinki, Finland.
Int J Environ Res Public Health. 2009 Dec;6(12):2934-49. doi: 10.3390/ijerph6122934. Epub 2009 Nov 27.
This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.
本研究旨在探讨活力耗竭 (VE) 和内皮功能障碍对颈动脉内膜中层厚度 (IMT) 评估的临床前动脉粥样硬化的交互作用。此外，还研究了 VE 与颈动脉弹性之间的相互作用。参与者为来自心血管风险在年轻芬兰人中的 1596 名年轻健康成年人。内皮功能障碍通过肱动脉血流介导的扩张 (FMD) 进行测量，颈动脉弹性通过颈动脉顺应性 (CAC) 进行测量。在 FMD 和 CAC 极低的参与者中，发现 FMD 和 VE 之间以及 CAC 和 VE 之间与 IMT 的显著交互作用。因此，如果内皮功能不正常，VE 可能是有害的。
