乳腺癌、皮肤纤维瘤与砷
Breast cancer, dermatofibromas and arsenic.
作者信息
Dantzig Paul I
机构信息
Department of Dermatology, Columbia University School of Medicine, New York 10022, USA.
出版信息
Indian J Dermatol. 2009;54(1):23-5. doi: 10.4103/0019-5154.48981.
BACKGROUND
Dermatofibromas are common benign tumors in women, and breast cancer is the most common malignancy in women. The aim of this study is to determine if there is any relationship between the two conditions.
MATERIALS AND METHODS
Five patients with dermatofibromas and 10 control patients (two groups) had their skin biopsies measured for arsenic by inductively coupled mass spectrometry. Fifty randomly selected patients with breast cancer and 50 control patients were examined for the presence of dermatofibromas.
RESULTS
The dermatofibromas were found to have an arsenic concentration of 0.171 micrograms/gram, compared with 0.06 and 0.07 micrograms/gram of the two control groups. Forty-three out of 50 patients with breast cancer had dermatofibromas and 32/50 patients with breast cancer had multiple dermatofibromas, compared to 10/50 control patients with dermatofibromas and only 1/50 with multiple dermatofibromas.
CONCLUSIONS
Arsenic is important in the development of dermatofibromas and dermatofibromas represent a reservoir and important sign of chronic arsenic exposure. Dermatofibromas represent an important sign for women at risk for breast cancer, and arsenic may represent the cause of the majority of cases of breast cancer.
背景
皮肤纤维瘤是女性常见的良性肿瘤，而乳腺癌是女性最常见的恶性肿瘤。本研究的目的是确定这两种病症之间是否存在任何关联。
材料与方法
对5例皮肤纤维瘤患者和10例对照患者（两组）的皮肤活检样本采用电感耦合质谱法测定砷含量。随机选取50例乳腺癌患者和50例对照患者，检查是否存在皮肤纤维瘤。
结果
发现皮肤纤维瘤的砷浓度为0.171微克/克，而两个对照组的浓度分别为0.06微克/克和0.07微克/克。50例乳腺癌患者中有43例患有皮肤纤维瘤，其中32例有多个皮肤纤维瘤；相比之下，50例对照患者中有10例患有皮肤纤维瘤，只有1例有多个皮肤纤维瘤。
结论
砷在皮肤纤维瘤的发生发展中起重要作用，皮肤纤维瘤是慢性砷暴露的一个蓄积部位和重要标志。皮肤纤维瘤是乳腺癌高危女性的一个重要标志，砷可能是大多数乳腺癌病例的病因。
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