Beatrous Surget V, Riahi Ryan R, Grisoli Stratton B, Cohen Philip R
Department of Internal Medicine, Scripps Mercy Hospital, San Diego, California.
Dermatol Online J. 2017 Sep 22;23(9):13030/qt8zv852d8.
Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Nine dermatofibromas developed in a woman with hypothyroidism, optic neuritis, and Arnold Chiari I malformation. Five dermatofibromas developed in a woman with breast cancer who had received several systemic antineoplastic therapies. Eleven dermatofibromas developed in a man with HIV whose systemic therapies included acyclovir, darunavir/cobicistat, dolutegravir, etravirine, and ritonavir. Conditions associated with multiple dermatofibromas include autoimmune diseases, cancer, chromosomal abnormalities, immunodeficiencies, metabolic disturbances, and altered physiologic states such as pregnancy. Medications received by patients with multiple dermatofibromas included immunosuppressive agents, psoriasis therapies, and antineoplastic drugs. Multiple dermatofibromas can be observed in patients with associated medical conditions, systemic therapies, or both. Therefore, in individuals presenting with multiple dermatofibromas, not only evaluation for associated disorders, but also review of prior and current drug therapies, should be considered.
皮肤纤维瘤是一种良性的、纤维组织细胞性的皮肤肿瘤。孤立性皮肤纤维瘤可能是偶然发现，而多发性皮肤纤维瘤可能与全身性疾病或既往治疗有关。本文描述了两名女性和一名男性患有多发性皮肤纤维瘤，并伴有全身性疾病、免疫抑制或两者皆有。一名患有甲状腺功能减退、视神经炎和阿诺德·奇亚里I型畸形的女性身上出现了9个皮肤纤维瘤。一名患有乳腺癌且接受过多种全身性抗肿瘤治疗的女性身上出现了5个皮肤纤维瘤。一名感染HIV的男性身上出现了11个皮肤纤维瘤，其全身性治疗包括阿昔洛韦、达芦那韦/考比司他、多替拉韦、依曲韦林和利托那韦。与多发性皮肤纤维瘤相关的疾病包括自身免疫性疾病、癌症、染色体异常、免疫缺陷、代谢紊乱以及生理状态改变（如妊娠）。患有多发性皮肤纤维瘤的患者所接受的药物包括免疫抑制剂、银屑病治疗药物和抗肿瘤药物。在患有相关疾病、接受全身性治疗或两者皆有的患者中可观察到多发性皮肤纤维瘤。因此，对于出现多发性皮肤纤维瘤的个体，不仅应评估相关疾病，还应审查既往和当前的药物治疗情况。
