Malik Archana, Sood Sunandan, Narang Subina
Department of Ophthalmology, Government Medical College Hospital, Sector 32a, Chandigarh, 160032, India.
Int Ophthalmol. 2010 Aug;30(4):425-8. doi: 10.1007/s10792-009-9337-4. Epub 2010 Jan 5.
We report a rare association of choroidal neovascularization (CNV) with retinitis pigmentosa and note its resolution by intravitreal injection of the anti-vascular endothelial growth factor (VEGF), bevacizumab. A classic choroidal neovascular membrane was seen in the right eye (RE) of a patient with sector retinitis pigmentosa. Bevacizumab 1.25 mg in 0.05 ml was injected intravitreally. The choroidal neovascular membrane was seen to regress following this single intravitreal bevacizumab injection with formation of a scar. CNV has very rarely been seen in association with retinitis pigmentosa. Anti-VEGF drugs have been shown to have a beneficial role in CNV with other causes; in this case their effectiveness in CNV associated with retinal dystrophies, for example retinitis pigmentosa, has been demonstrated.
我们报告了一例脉络膜新生血管（CNV）与色素性视网膜炎罕见关联的病例，并指出通过玻璃体内注射抗血管内皮生长因子（VEGF）药物贝伐单抗可使其消退。在一名患有扇形色素性视网膜炎患者的右眼（RE）中发现了典型的脉络膜新生血管膜。将0.05 ml含1.25 mg贝伐单抗的溶液玻璃体内注射。单次玻璃体内注射贝伐单抗后，可见脉络膜新生血管膜消退并形成瘢痕。CNV与色素性视网膜炎相关的情况极为罕见。抗VEGF药物已被证明在其他原因引起的CNV中具有有益作用；在本病例中，已证实其在与视网膜营养不良（如色素性视网膜炎）相关的CNV中有效。
