Iwakiri Ryo, Okinami Satoshi, Hirata Akira
Department of Ophthalmology, Saga University Faculty of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 2007 Aug;111(8):606-11.
To report two cases of retinitis pigmentosa in which choroidal neovascularization developed.
The first case was a 50-year-old man with retinitis pigmentosa. In his left eye, choroidal neovascularization developed at the upper side of the fovea. Visual acuity in the eye was 0.3 at the first visit, and had decreased to 0.04 at a 14-year follow-up. The second case was a 60-year-old man with retinitis pigmentosa. Subfoveal choroidal neovascularization had developed in his right eye. Visual acuity in the eye was 0.03 at the first visit, and had decreased to hand motion at a 15-year follow-up.
These cases are the first reports of the coincidence of retinitis pigmentosa and choroidal neovascularization in Japan. Although the etiology is unknown, genetic investigation might be useful to clarify the association between retinitis pigmentosa and choroidal neovascularization.
报告两例发生脉络膜新生血管的视网膜色素变性病例。
首例病例为一名50岁的视网膜色素变性男性。其左眼，在黄斑中心凹上方出现脉络膜新生血管。该眼初诊时视力为0.3，在14年的随访中降至0.04。第二例病例是一名60岁的视网膜色素变性男性。其右眼出现黄斑下脉络膜新生血管。该眼初诊时视力为0.03，在15年的随访中降至手动视力。
这些病例是日本关于视网膜色素变性与脉络膜新生血管并存的首例报告。尽管病因不明，但基因研究可能有助于阐明视网膜色素变性与脉络膜新生血管之间的关联。
