Kutcher S, Marton P
Division of Adolescent Psychiatry, Sunnybrook Health Science Centre, Toronto.
J Am Acad Child Adolesc Psychiatry. 1991 Jan;30(1):75-8. doi: 10.1097/00004583-199101000-00011.
Two hundred and fifty-nine first-degree relatives of 23 adolescent bipolars (81 relatives); 26 unipolars (95 relatives); and 24 normal controls (83 relatives) were assessed for the presence of affective disorders, using the family history method. First-degree relatives of bipolar probands were significantly more likely to have a bipolar illness than those of unipolar probands (p = 0.03) and normal controls (p = 0.001). Rates of unipolar depression in first-degree relatives of bipolars and unipolars were not significantly different but differed significantly between bipolars and normals (p = 0.002) and unipolars and normals (p = 0.006). The implications of these findings for clinical work, diagnosis, and research in adolescents with affective disorders are discussed.
采用家族史方法，对23名青少年双相情感障碍患者的259名一级亲属（81名亲属）、26名单相情感障碍患者的95名亲属以及24名正常对照者的83名亲属进行情感障碍评估。双相情感障碍先证者的一级亲属患双相情感障碍的可能性显著高于单相情感障碍先证者的一级亲属（p = 0.03）和正常对照者的一级亲属（p = 0.001）。双相情感障碍患者和单相情感障碍患者的一级亲属中单相抑郁症的发病率无显著差异，但双相情感障碍患者与正常对照者之间（p = 0.002）以及单相情感障碍患者与正常对照者之间（p = 0.006）存在显著差异。本文讨论了这些发现对青少年情感障碍临床工作、诊断和研究的意义。
