Hoehn-Saric R, Harris G J, Pearlson G D, Cox C S, Machlin S R, Camargo E E
Johns Hopkins Medical Institutions Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.
J Clin Psychiatry. 1991 Mar;52(3):131-3.
The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.
作者报告了一名服用高剂量氟西汀的强迫症患者出现了冷漠、无动于衷、注意力不集中和持续言语的情况。这些变化与额叶脑血流量减少以及通常与额叶损伤相关的神经心理测试变化有关。在停用氟西汀4周后，这些临床表现消失了。
