氟西汀对强迫症患者局部脑血流的影响。
Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients.
作者信息
Hoehn-Saric R, Pearlson G D, Harris G J, Machlin S R, Camargo E E
机构信息
Department of Psychiatry, Johns Hopkins Hospital, Baltimore, MD 21205.
出版信息
Am J Psychiatry. 1991 Sep;148(9):1243-5. doi: 10.1176/ajp.148.9.1243.
PMID:1883007
Abstract
Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
摘要
六名未服用药物的强迫症患者在接受氟西汀治疗前和治疗期间进行了单光子发射计算机断层扫描。治疗显著降低了患者的“额叶功能亢进”，这是通过内侧额叶与整个大脑皮层血流的比率来确定的，同时显著降低了强迫症和焦虑症状的评分。
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