Columbia University Mailman School of Public Health, New York, NY, USA.
Biomarkers. 2010 Feb;15(1):20-30. doi: 10.3109/13547500903186452.
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
该研究对欧洲癌症前瞻性调查与营养研究中 230 例肺癌病例和 648 例对照进行了嵌套分析，调查了体力活动、潜在中间生物标志物与肺癌风险之间的关系。研究获得了一部分病例和对照的白细胞芳香族-DNA 加合物和红细胞谷胱甘肽（GSH）的数据。与第一四分位数相比，休闲体力活动的第四四分位数与较低的肺癌风险相关（比值比（OR）0.56，95%置信区间（CI）0.35-0.90），GSH 水平较高（+1.87 μmol GSH/g 血红蛋白，p=0.04），但与高加合物水平无关（OR 1.05，95%CI 0.38-2.86）。尽管与休闲体力活动相关，但在这些小规模的初步分析中，GSH 水平与肺癌风险无关（GSH 水平每增加一个单位，OR 为 0.95，95%CI 为 0.84-1.07）。家庭和职业活动与肺癌风险或生物标志物水平无关。
