Department of Primary Health Care, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
BMC Fam Pract. 2010 Jan 5;11:1. doi: 10.1186/1471-2296-11-1.
The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets.
Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models.
This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853).
We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
Charlson 合并症指数在 ICD-9 管理数据中被广泛使用，但对于 Read/OXMIS 编码数据，尽管其使用量不断增加，却没有相应的翻译。我们的主要目标是将 Charlson 指数翻译成适用于 Read/OXMIS 编码数据的形式，如 GPRD，并测试其与死亡率的相关性。我们还旨在为使用类似数据集的其他研究人员提供一种版本的合并症指数。
两位临床医生将 Charlson 指数翻译成 Read/OXMIS 代码。我们使用比例风险模型在来自 GPRD 的 146441 名患者中测试了合并症评分与死亡率增加之间的相关性。
这种 Read/OXMIS 翻译的 Charlson 指数包含 3156 个代码。我们的验证表明 Charlson 评分与年龄之间存在很强的正相关关系。Cox 比例模型显示与死亡率和 Charlson 评分呈正相关的递增关系。用于死亡率的逻辑回归模型的判别能力良好（AUC = 0.853）。
我们已经将一种常用的合并症指数翻译成适用于英国初级保健数据库的 Read/OXMIS。在我们的研究人群中，该翻译指数表现出良好的判别能力。这是第一项为 Read/OXMIS 编码系统和 GPRD 开发合并症指数的研究。为使用类似数据库的其他研究人员提供了一份合并症指数副本。
