Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, 140 Han Zhong Road, Nanjing 210029, China.
J Ethnopharmacol. 2010 Apr 21;128(3):649-53. doi: 10.1016/j.jep.2009.12.041. Epub 2010 Jan 4.
Wujijing Oral Liquid (WJJ) contained principally the flesh essence of the black-boned chicken. As a kind of food and medicine in China, it was used to treat the menstrual disturbance traditionally, but the exact mechanism of the action was not yet clear. The clinical effects of the WJJ on the symptoms of the menstrual disturbance and the reproductive hormones were studied in this paper.
The 53 women with the menstrual disturbance were selected as the study object, and then they were randomly divided to receive either WJJ 10mL twice daily (n=28) or the placebo (n=25) from the 1st day after menstrual flow for 2 menstrual cycles. On the 1st day after the discontinuation of the medication but before the treatment, the scores for the menstrual pattern and the related symptoms were obtained and the blood samples were collected to test the reproductive hormones. The serum levels of the follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and estradiol (E2) were examined by enzyme-linked immunosorbent assay (ELISA). The levels of progesterone (P) and testosterone (T) in serum were measured by the radioimmunoassay.
The score for the primary and related symptoms of the menstruation was increased significantly among patients treated with the WJJ. The differences on the FSH, PRL, and E2 levels of patients were significant before and after the treatment with WJJ. Comparing the WJJ group and the placebo group, the levels of P and T differed significantly after treatment. The oral liquid of WJJ was found to be safe, as it did not cause any change in the hepatic and renal functional parameters.
The oral liquid of Wujijing could improve the menstrual disturbance and were generally safe and well tolerated. The possible mechanism could be associated with its effects in reinforcing the kidney and regulating the hypothalamus-pituitary-ovary axis (HPOA).
乌鸡金精口服液（WJJ）主要含有乌骨鸡的肉精华。作为中国的一种药食同源的产品，它传统上被用于治疗月经失调，但确切的作用机制尚不清楚。本文研究了 WJJ 对月经失调症状和生殖激素的临床疗效。
选择 53 例月经失调患者作为研究对象，随机分为 WJJ 组（n=28）和安慰剂组（n=25）。WJJ 组从月经来潮后第 1 天开始，每天口服 10mL，每日 2 次，连续服用 2 个月经周期；安慰剂组则在月经第 1 天开始服用，连续服用 2 个月经周期。停药前 1 天，评估月经模式和相关症状评分，并采集血样检测生殖激素。采用酶联免疫吸附试验（ELISA）检测卵泡刺激素（FSH）、黄体生成素（LH）、催乳素（PRL）和雌二醇（E2）的血清水平，放射免疫法检测血清孕酮（P）和睾酮（T）水平。
WJJ 治疗组患者的主要和相关症状评分显著增加。WJJ 治疗前后 FSH、PRL 和 E2 水平差异有统计学意义。与安慰剂组相比，WJJ 治疗后 P 和 T 水平差异有统计学意义。WJJ 口服液安全性良好，未引起肝肾功能参数的变化。
乌鸡金精口服液可改善月经失调，一般安全且耐受良好。其作用机制可能与补肾、调节下丘脑-垂体-卵巢轴（HPOA）有关。
