针对鸟氨酸脱羧酶预防人类非黑素瘤皮肤癌。
Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.
机构信息
Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294-0019, USA.
出版信息
Cancer Prev Res (Phila). 2010 Jan;3(1):8-11. doi: 10.1158/1940-6207.CAPR-09-0248.
Abstract
Bailey et al. report in this issue of the journal (beginning on page 35) one of the first successful trials of basal cell carcinoma (BCC) prevention. Oral alpha-difluoromethyl-dl-ornithine (DFMO) reduced new BCCs in patients with a prior history of nonmelanoma skin cancer. DFMO is an inhibitor of ornithine decarboxylase, a key enzyme in the polyamine biosynthetic pathway. This perspective on Bailey et al. discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention.
摘要
贝利等人在本期杂志（第 35 页开始）报告了基底细胞癌（BCC）预防的首次成功试验之一。口服α-二氟甲基-dl-鸟氨酸（DFMO）可减少有非黑色素瘤皮肤癌既往史的患者新发生的 BCC。DFMO 是鸟氨酸脱羧酶的抑制剂，鸟氨酸脱羧酶是多胺生物合成途径中的关键酶。对贝利等人的这一观点进行了讨论，内容涉及多胺对 BCC 发病机制的作用、这方面的认识如何促进预防 BCC 的新方法的发展，以及 DFMO 预防 BCC 的未来研究前景。
相似文献
1
Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.针对鸟氨酸脱羧酶预防人类非黑素瘤皮肤癌。
Cancer Prev Res (Phila). 2010 Jan;3(1):8-11. doi: 10.1158/1940-6207.CAPR-09-0248.
2
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.一项随机、双盲、安慰剂对照的 III 期皮肤癌预防研究，评估 α-二氟甲基鸟氨酸在既往有皮肤癌病史的受试者中的应用。
Cancer Prev Res (Phila). 2010 Jan;3(1):35-47. doi: 10.1158/1940-6207.CAPR-09-0096.
3
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.鸟氨酸脱羧酶是Ptch1+/-小鼠基底细胞癌和鳞状细胞癌化学预防的靶点。
J Clin Invest. 2004 Mar;113(6):867-75. doi: 10.1172/JCI20732.
4
Polyamines and nonmelanoma skin cancer.多胺与非黑色素瘤皮肤癌
Toxicol Appl Pharmacol. 2007 Nov 1;224(3):249-56. doi: 10.1016/j.taap.2006.11.023. Epub 2006 Nov 29.
5
Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent.多胺生物合成抑制剂2-（二氟甲基）鸟氨酸（DFMO）作为癌症化学预防剂的复兴。
Biochem Soc Trans. 2007 Apr;35(Pt 2):353-5. doi: 10.1042/BST0350353.
6
Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine.使用特异性抑制剂α-二氟甲基鸟氨酸的衍生物对鸟氨酸脱羧酶进行荧光定位。
J Enzyme Inhib. 1989;3(2):133-43. doi: 10.3109/14756368909030372.
7
Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants.二氟甲基鸟氨酸在器官移植受者中的I期化学预防研究。
Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):657-61.
8
Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci.二氟甲基鸟氨酸（DFMO）和 AMXT1501 抑制肺炎球菌荚膜生物合成。
Sci Rep. 2022 Jul 12;12(1):11804. doi: 10.1038/s41598-022-16007-7.
9
10
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.DL-α-二氟甲基鸟氨酸（一种鸟氨酸脱羧酶的特异性不可逆抑制剂）对肿瘤促进作用的抑制。
Basic Life Sci. 1990;52:195-204. doi: 10.1007/978-1-4615-9561-8_16.
引用本文的文献
1
Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases.基于结构模拟的真菌鸟氨酸脱羧酶活性位点变异比较
Commun Integr Biol. 2025 Jan 31;18(1):2458872. doi: 10.1080/19420889.2025.2458872. eCollection 2025.
2
Preclinical evaluation of the third-generation, bi-steric mechanistic target of rapamycin complex 1-selective inhibitor RMC-6272 in -deficient models.雷帕霉素复合物1选择性抑制剂RMC-6272（第三代双立体机制靶点）在β-缺陷模型中的临床前评估。
Neurooncol Adv. 2024 Feb 16;6(1):vdae024. doi: 10.1093/noajnl/vdae024. eCollection 2024 Jan-Dec.
3
An update on clinical trials for chemoprevention of human skin cancer.人类皮肤癌化学预防临床试验的最新进展。
J Cancer Metastasis Treat. 2023;9(1). doi: 10.20517/2394-4722.2022.99. Epub 2023 Feb 27.
4
Non-melanoma skin cancer event rates in a formalized clinical trial setting: considerations for clinical trial design.在规范化临床试验环境下的非黑素瘤皮肤癌事件发生率：对临床试验设计的考虑。
Eur J Cancer Prev. 2024 Jan 1;33(1):69-72. doi: 10.1097/CEJ.0000000000000829. Epub 2023 Jul 3.
5
Microbial Metabolite Dysbiosis and Colorectal Cancer.微生物代谢物失调与结直肠癌
Gut Liver. 2023 Mar 15;17(2):190-203. doi: 10.5009/gnl220260. Epub 2023 Jan 12.
6
Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine.氰基-藻蓝蛋白：对人体皮肤的作用机制及医学应用前景
Plants (Basel). 2022 May 5;11(9):1249. doi: 10.3390/plants11091249.
7
Untargeted Metabolomics of Breast Cancer Cells MCF-7 and SkBr3 Treated With Tamoxifen/Trastuzumab.他莫昔芬/曲妥珠单抗处理的乳腺癌细胞 MCF-7 和 SkBr3 的非靶向代谢组学研究。
Cancer Genomics Proteomics. 2022 Jan-Feb;19(1):79-93. doi: 10.21873/cgp.20305.
8
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study.精脒氧化酶活性的遗传调控与癌症风险：一项孟德尔随机化研究。
Sci Rep. 2021 Aug 31;11(1):17463. doi: 10.1038/s41598-021-97069-x.
9
The First Insight Into the Supramolecular System of -α-Difluoromethylornithine: A New Antiviral Perspective.对α-二氟甲基鸟氨酸超分子系统的初步洞察：一个新的抗病毒视角。
Front Chem. 2021 May 13;9:679776. doi: 10.3389/fchem.2021.679776. eCollection 2021.
10
Polyamines and related signaling pathways in cancer.癌症中的多胺及相关信号通路
Cancer Cell Int. 2020 Nov 5;20(1):539. doi: 10.1186/s12935-020-01545-9.
本文引用的文献
1
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.一项随机、双盲、安慰剂对照的 III 期皮肤癌预防研究，评估 α-二氟甲基鸟氨酸在既往有皮肤癌病史的受试者中的应用。
Cancer Prev Res (Phila). 2010 Jan;3(1):35-47. doi: 10.1158/1940-6207.CAPR-09-0096.
2
Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice.非甾体类抗炎药在遗传易感的 PTCH1+/- 人类和小鼠基底细胞癌化学预防中的作用。
Cancer Prev Res (Phila). 2010 Jan;3(1):25-34. doi: 10.1158/1940-6207.CAPR-09-0200.
3
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.鸟氨酸脱羧酶基因多态性与结直肠癌生存率的关联。
Clin Cancer Res. 2009 Oct 1;15(19):6208-16. doi: 10.1158/1078-0432.CCR-09-0592. Epub 2009 Sep 29.
4
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.破坏多胺稳态作为神经母细胞瘤的一种治疗策略。
Clin Cancer Res. 2009 Oct 1;15(19):5956-61. doi: 10.1158/1078-0432.CCR-08-3213. Epub 2009 Sep 29.
5
Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study.预防器官移植患者非黑素瘤皮肤癌的研究：一项 24 个月前瞻性病例对照研究。
Br J Dermatol. 2009 Nov;161 Suppl 3:78-84. doi: 10.1111/j.1365-2133.2009.09453.x.
6
Does chronic sunscreen use reduce vitamin D production to insufficient levels?长期使用防晒霜会否导致维生素 D 生成不足？
Br J Dermatol. 2009 Oct;161(4):732-6. doi: 10.1111/j.1365-2133.2009.09332.x. Epub 2009 Jun 4.
7
Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.在一项关于二氟甲基鸟氨酸和舒林酸预防散发性结肠直肠腺瘤的III期临床试验中对气导听力图的纵向评估。
Cancer Prev Res (Phila). 2008 Dec;1(7):514-21. doi: 10.1158/1940-6207.CAPR-08-0074.
8
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.精胺合酶缺乏会导致耳聋以及对α-二氟甲基鸟氨酸极度敏感。
J Biol Chem. 2009 Jan 9;284(2):930-7. doi: 10.1074/jbc.M807758200. Epub 2008 Nov 10.
9
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.二氟甲基鸟氨酸联合舒林酸预防散发性结直肠腺瘤：一项随机安慰剂对照双盲试验
Cancer Prev Res (Phila). 2008 Jun;1(1):32-8. doi: 10.1158/1940-6207.CAPR-08-0042.
10
Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.鸟氨酸脱羧酶G316A基因型对结直肠腺瘤复发具有预后价值，并可预测阿司匹林化学预防的疗效。
Clin Cancer Res. 2008 Apr 15;14(8):2303-9. doi: 10.1158/1078-0432.CCR-07-4599.
Zotero 插件