2007: signaling breakthroughs of the year.

This year's notable advances in cell signaling span research into the signals that regulate the state of chromatin in the cell nucleus to those signals that modulate the social behavior of organisms. This year's findings include unexpected mechanisms and players in immune signaling pathways; new insights into the mechanisms underlying cell differentiation and development; lessons from model organisms regarding organismal behavior; revelations regarding the dynamics of cell signaling pathways; increasing recognition of the ubiquity and complexity of ubiquitin and related molecules in signaling processes; and a family of channels that have cornered the market on peripheral sensory perception.