Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan.
Endocr J. 2010;57(4):293-301. doi: 10.1507/endocrj.k09e-305. Epub 2010 Jan 6.
The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (> or = 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.
采用日本塔原社区为基础的人群（n（男/女）：2639（1168/1470）；年龄：63.0±10.2 岁），研究了 FTO 基因多态性 rs9939609 与肥胖的关系。还研究了生活方式相关因素（包括营养摄入和体力活动）对该关联的影响。体质指数（BMI）与 FTO 基因多态性显著相关（p＜0.001）。使用多因素逻辑回归分析对 FTO 基因多态性与肥胖的病例对照关联研究表明，在调整年龄和性别后，基因型 AA（比值比，1.53[95%置信区间，1.04-2.24]）与肥胖显著相关。对基因型组之间与生活方式相关因素的差异进行分析显示，中等强度至高强度体力活动（PA）（＞或＝3.0 METs）的能量消耗存在显著差异（p=0.012），基因型 AA 呈显著下降趋势（p=0.027）。然后，使用基于中等强度至高强度 PA 能量消耗的研究组（低 PA 和高 PA），对该多态性与肥胖的关联的 PA 能量消耗的影响进行了检验。在低 PA 组中，基因型 AA 的 BMI 显著较高（p=0.016），而在高 PA 组中则不然（p=0.103）。此外，在低 PA 组中，基因型 AA 与肥胖显著相关（比值比，2.39[95%置信区间，1.19-4.80]），而在高 PA 组中则不然（p=0.650）。FTO 基因 rs9939609 与肥胖相关，在低 PA 人群中该关联明显，表明存在 PA 依赖性关联。
