Petkeviciene J, Smalinskiene A, Klumbiene J, Petkevicius V, Kriaucioniene V, Lesauskaite V
Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Tilzes 18, LT-47181 Kaunas, Lithuania.
Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, LT-50009 Kaunas, Lithuania.
Public Health. 2016 Jun;135:23-9. doi: 10.1016/j.puhe.2016.02.009. Epub 2016 Mar 19.
This study aimed to examine the associations between the fat mass and obesity associated (FTO) gene rs9939609 variant with obesity and metabolic syndrome and interactions between FTO alleles, dietary intake and physical activity in Lithuanian adult population.
Cross-sectional study.
A health survey was carried out in randomly selected municipalities of Lithuania. The random sample was obtained from the lists of 25-64 year-old inhabitants. The data from 1020 individuals were analyzed. The single-nucleotide polymorphism, rs9939609, in the FTO gene was assessed using a real-time polymerase chain reaction. 24-hour recall was used for evaluation of dietary habits. Information on physical activity at work, traveling to and from work and at leisure time was gathered by a standard questionnaire.
The carriers of the AA genotype had the highest mean values of body mass index (BMI) and waist circumference (WC). They had 1.72 time higher odds of obesity (P = 0.009) and 1.67 time higher odds of increased WC (P = 0.013) than those with the TT genotype. Carriers of the T allele had lower prevalence of metabolic syndrome compared to carriers of the AA genotype (33.8% and 42.5% respectively; P = 0.018). No interaction between the rs9939609 variant and energy or dietary intakes on weight status was found. Significant effect of the interactions 'genotype×age' and 'genotype×physical activity' on BMI was demonstrated. The FTO rs9939609 polymorphism was associated with anthropometric parameters and metabolic syndrome in the younger age group (25-44 years) and in individuals having low level of physical activity.
Age and physical activity modulated the effect of the FTO polymorphism on weight status and metabolic syndrome in Lithuanian adult population.
本研究旨在探讨脂肪量和肥胖相关（FTO）基因rs9939609变异与肥胖及代谢综合征之间的关联，以及立陶宛成年人群中FTO等位基因、饮食摄入和身体活动之间的相互作用。
横断面研究。
在立陶宛随机选取的城市进行健康调查。随机样本来自25至64岁居民名单。对1020名个体的数据进行分析。使用实时聚合酶链反应评估FTO基因中的单核苷酸多态性rs9939609。采用24小时回顾法评估饮食习惯。通过标准问卷收集工作、上下班途中及休闲时间的身体活动信息。
AA基因型携带者的体重指数（BMI）和腰围（WC）平均值最高。与TT基因型携带者相比，他们肥胖的几率高1.72倍（P = 0.009），WC增加的几率高1.67倍（P = 0.013）。与AA基因型携带者相比，T等位基因携带者的代谢综合征患病率较低（分别为33.8%和42.5%；P = 0.018）。未发现rs9939609变异与能量或饮食摄入对体重状况的相互作用。证实了“基因型×年龄”和“基因型×身体活动”相互作用对BMI有显著影响。FTO rs9939609多态性与年轻年龄组（25至44岁）及身体活动水平低的个体的人体测量参数和代谢综合征相关。
年龄和身体活动调节了FTO多态性对立陶宛成年人群体重状况和代谢综合征的影响。
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