First Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Endocr J. 2010;57(4):287-92. doi: 10.1507/endocrj.k09e-283. Epub 2010 Jan 6.
Patients with unresectable parathyroid carcinoma develop severe hypercalcemia, bone fractures and renal failure, and become unresponsive to conventional treatments. It has been shown that successful induction of anti-parathyroid hormone (PTH) antibodies, using PTH peptide fragments for immunisation, normalized serum levels of calcium as well as improved clinical symptoms. Here, we report our experience of PTH immunization in a Japanese female suffering from refractory hypercalcemia and renal failure caused by unresectable metastatic parathyroid carcinoma. Upon immunization, there were apparent clinical responses including reduction of serum levels of Ca along with anti-PTH antibodies induction. Therefore, we concluded that PTH immunization was an effective treatment against hypercalcemia caused by metastatic parathyroid carcinomas that are unresponsive to conventional treatments.
无法手术的甲状旁腺癌患者会出现严重的高钙血症、骨折和肾衰竭，并且对常规治疗无反应。已经表明，使用甲状旁腺激素（PTH）肽片段进行免疫接种，成功诱导抗 PTH 抗体，可以使血清钙水平正常化，并改善临床症状。在这里，我们报告了一例日本女性的 PTH 免疫接种经验，该女性患有无法切除的转移性甲状旁腺癌引起的难治性高钙血症和肾衰竭。免疫接种后，出现了明显的临床反应，包括血清 Ca 水平降低和抗 PTH 抗体的诱导。因此，我们得出结论，PTH 免疫接种是治疗对常规治疗无反应的转移性甲状旁腺癌引起的高钙血症的有效方法。
