Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Digestion. 2010;81(1):20-6. doi: 10.1159/000217451. Epub 2009 Dec 30.
Colorectal neoplasia and cardiovascular disease appear to share common risk factors. This study aimed to investigate the association between the thickness of the intima-media complex (IMT) or carotid artery stenosis (CAS) on carotid artery ultrasonography and the presence of colorectal adenomas in middle-aged asymptomatic men.
This study was conducted among 1,877 asymptomatic male subjects, 40-59 years, who underwent both carotid artery ultrasonography and colonoscopy for routine health examination. Clinical information was collected from a standardized questionnaire, physical examination and blood tests.
The prevalence of overall colorectal adenomatous polyps (APs) was 31.4% (591/1,877). The subjects were divided into two groups according to the presence of APs in the colorectum. The prevalence of IMT >or=10 mm was significantly higher in the subjects with CAS than in those without CAS (10.1 vs. 0.7%, p < 0.001). CAS was more prevalent in the AP-positive group than in the AP-negative group (40.5 vs. 30.2%, p = 0.001). Moreover, CAS was more prevalent in the advanced AP-positive group than in the advanced AP-negative group (15.2 vs. 8.2%, p = 0.048).
This study suggests that there is a relationship between colorectal AP and CAS, probably due to common risk factors.
结直肠肿瘤和心血管疾病似乎具有共同的危险因素。本研究旨在探讨颈动脉超声检查中内-中膜厚度（IMT）或颈动脉狭窄（CAS）与中年无症状男性结直肠腺瘤之间的关系。
本研究纳入了 1877 名无症状的 40-59 岁男性，他们因常规健康检查而行颈动脉超声检查和结肠镜检查。临床信息通过标准化问卷、体格检查和血液检查收集。
结直肠腺瘤性息肉（AP）的总患病率为 31.4%（591/1877）。根据结直肠是否存在 AP，将受试者分为两组。有 CAS 的受试者中 IMT≥10mm 的患病率明显高于无 CAS 的受试者（10.1% vs. 0.7%，p<0.001）。AP 阳性组的 CAS 患病率高于 AP 阴性组（40.5% vs. 30.2%，p=0.001）。此外，AP 阳性的高级别组的 CAS 患病率高于 AP 阴性的高级别组（15.2% vs. 8.2%，p=0.048）。
本研究表明结直肠 AP 与 CAS 之间存在关联，可能与共同的危险因素有关。
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