Department of Family Medicine, Yonsei University College of Medicine, Yongin-city, Gyeonggi-do, Korea.
J Womens Health (Larchmt). 2011 May;20(5):765-9. doi: 10.1089/jwh.2010.2538. Epub 2011 Mar 31.
Colorectal adenomatous polyp is a precancerous lesion, and some studies have documented its link with cardiovascular risk factors. This study aimed to investigate the association between arterial stiffness and colorectal adenomatous polyp.
Among 388 Korean women, we examined the association between brachial-ankle pulse wave velocity (baPWV) as a measurement of arterial stiffness and the presence of colorectal adenomatous polyp as determined by colonoscopy. baPWV values were categorized separately as follows: ≤1199 cm/s, 1200-1399 cm/s, 1400-1599 cm/s and ≥1600 cm/s. The odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal adenomatous polyp were calculated across each group of PWVs.
The prevalence of colorectal adenomatous polyp was 9.5%. After adjusting for age, body mass index (BMI), cigarette smoking, blood pressure, fasting plasma glucose, and triglycerides, the ORs (95% CIs) for colorectal adenomatous polyp according to each of the four groups of baPWV were 1.00, 2.89 (0.52-15.98), 3.27 (0.48-22.24), and 11.17 (1.17-106.99).
A higher level of baPWV was found to be independently associated with the presence of colorectal adenomatous polyp, regardless of classic cardiovascular risk factors and other components of metabolic syndrome in women.
结直肠腺瘤性息肉是一种癌前病变，一些研究已经证明其与心血管危险因素有关。本研究旨在探讨动脉僵硬与结直肠腺瘤性息肉之间的关系。
在 388 名韩国女性中，我们检查了肱踝脉搏波速度（baPWV）作为动脉僵硬的测量值与结肠镜检查确定的结直肠腺瘤性息肉之间的关系。baPWV 值分别分为以下几类：≤1199cm/s、1200-1399cm/s、1400-1599cm/s 和≥1600cm/s。计算了每组 PWV 下结直肠腺瘤性息肉的比值比（OR）和 95%置信区间（CI）。
结直肠腺瘤性息肉的患病率为 9.5%。在校正年龄、体重指数（BMI）、吸烟、血压、空腹血糖和甘油三酯后，baPWV 四组的结直肠腺瘤性息肉 OR（95%CI）分别为 1.00、2.89（0.52-15.98）、3.27（0.48-22.24）和 11.17（1.17-106.99）。
无论女性是否存在经典心血管危险因素和代谢综合征的其他成分，较高的 baPWV 水平与结直肠腺瘤性息肉的存在均呈独立相关。
