Moschovi Maria, Trimis Georgios, Vounatsou Maria, Katsibardi Katerina, Margeli Alexandra, Damianos Andreas, Chrousos George, Papassotiriou Ioannis
Pediatric Hematology/Oncology double daggerEndocrinology, Metabolism and Diabetes Units, First Department of Pediatrics, Athens University Medical School, Aghia Sophia"Children's Hospital, Athens, Greece.
J Pediatr Hematol Oncol. 2010 Jan;32(1):e8-13. doi: 10.1097/MPH.0b013e3181b8a50c.
To investigate adipocytokine secretion, at diagnosis and during chemotherapy in children with the acute lymphoblastic leukemia (ALL).
Serial measurements (6/patient) of the anti-inflammatory cytokine adiponectin and the proinflammatory adipocytokines leptin and resistin were performed at diagnosis and in nearly the entire period of therapy (up to 21 months), in 9 patients with ALL aged 2 to 7 years (median 4.3 y). Body mass index and leukemic burden were estimated at the same time points and correlated with adipocytokine levels. Nine healthy children matched for age, sex, and body mass index were used as controls.
At diagnosis, mean adiponectin levels were low (P<0.001) and mean leptin and resistin levels were high, compared with controls (P<0.001). During maintenance phase, adiponectin increased significantly (P=0.024), whereas leptin and resistin decreased (P=0.018 and P=0.020, respectively), compared with baseline values. However, adiponectin, despite its progressive increase, remained at lower levels toward the end of the maintenance phase, compared with controls, (P<0.001). Delta (final-baseline) mean adiponectin was negatively correlated with leukemic burden (P=0.019), whereas delta mean leptin and resistin were positively correlated with it (P=0.011 and P=0.031, respectively).
Low-plasma adiponectin and high leptin and resistin level are present at the ALL diagnosis. Adipocytokines alterations are progressively restored during therapy.
研究急性淋巴细胞白血病（ALL）患儿在诊断时及化疗期间的脂肪细胞因子分泌情况。
对9名年龄在2至7岁（中位年龄4.3岁）的ALL患儿在诊断时以及几乎整个治疗期间（长达21个月）进行了系列测量（每位患者6次），测量了抗炎细胞因子脂联素以及促炎脂肪细胞因子瘦素和抵抗素。同时在相同时间点估算体重指数和白血病负荷，并将其与脂肪细胞因子水平进行关联。选取9名年龄、性别和体重指数匹配的健康儿童作为对照。
与对照组相比，诊断时脂联素平均水平较低（P<0.001），瘦素和抵抗素平均水平较高（P<0.001）。在维持治疗阶段，与基线值相比，脂联素显著升高（P=0.024），而瘦素和抵抗素降低（分别为P=0.018和P=0.020）。然而，尽管脂联素持续升高，但在维持治疗阶段结束时，与对照组相比，其水平仍较低（P<0.001）。脂联素的平均变化值（最终值 - 基线值）与白血病负荷呈负相关（P=0.019），而瘦素和抵抗素的平均变化值与白血病负荷呈正相关（分别为P=0.011和P=0.031）。
ALL诊断时存在低血浆脂联素以及高瘦素和抵抗素水平。治疗期间脂肪细胞因子的改变逐渐恢复。
