Division of Neurology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
J Head Trauma Rehabil. 2010 Jan-Feb;25(1):15-22. doi: 10.1097/HTR.0b013e3181c39960.
To explore whether children judged by their parents as showing an "excellent" or "complete" social reintegration after pediatric traumatic brain injury have less white matter volume (WMV) loss and better neuropsychological test scores than children who do not achieve this same level of reintegration.
Primary-care hospital/medical center.
Twenty-eight children with post-acute traumatic brain injury evaluated as outpatients.
Parental ratings of overall social reintegration, neuropsychological test performance, and voxel-based morphometry analysis of brain WMV loss.
In addition to showing worse neuropsychological test performance, children judged not to make a complete or excellent social reintegration had greater WMV loss, particularly within the corpus callosum. WMV loss in the corpus callosum correlated with the child's Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) Full Scale IQ (rho = .677, P = .000) and parental ratings of level of social integration (rho = .415, P = .028). Admitting Glasgow Coma Scale scores, mother's level of education, WISC-IV Processing Speed Index scores, and WMV loss in the region of the corpus callosum significantly contributed to parental ratings of a child's level of social reintegration.
Preliminary findings suggested that diffuse WMV loss, particularly in deep brain regions (eg, corpus callosum), may relate to the child's long-term psychosocial outcome as viewed from the parents' perspective.
探讨父母判断为在小儿创伤性脑损伤后表现出“优秀”或“完全”社会融合的儿童与未达到相同融合水平的儿童相比，其白质体积（WMV）损失是否更小，神经心理学测试得分是否更好。
初级保健医院/医疗中心。
28 名接受过创伤性脑损伤后急性期评估的门诊儿童。
父母对整体社会融合的评分、神经心理学测试表现以及大脑 WMV 损失的体素形态计量分析。
除了表现出较差的神经心理学测试表现外，父母判断未实现完全或优秀社会融合的儿童的 WMV 损失更大，特别是在胼胝体。胼胝体的 WMV 损失与儿童的韦氏儿童智力量表第四版（WISC-IV）全量表智商（rho =.677，P =.000）和父母对社会融合水平的评分呈正相关（rho =.415，P =.028）。格拉斯哥昏迷量表评分、母亲的受教育程度、WISC-IV 处理速度指数评分以及胼胝体区域的 WMV 损失均显著影响父母对儿童社会融合水平的评分。
初步结果表明，弥漫性 WMV 损失，特别是在深部脑区（如胼胝体），可能与儿童从父母角度看的长期心理社会结局有关。
