van Niekerk Catharina C, Bulten Johan, Vooijs G Peter, Verbeek André L M
Department of Epidemiology, Biostatistics, and Health Technology Assessment, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Obstet Gynecol Int. 2010;2010:465162. doi: 10.1155/2010/465162. Epub 2009 Dec 15.
Objective. Ovarian and endometrial cancers coincide rather frequently in the same patient. Few data are available on the involvement of the specific morphological subtypes. To identify histological pathways in the synchronous occurrence, a population-based study was performed in The Netherlands. Methods. Using the national pathology database (PALGA) information of ovarian cancers and of earlier or later cancer in the endometrium was obtained. 5366 Patients were identified with primary malignant epithelial or borderline malignancy. Results. In 157 cases (2.9%) a new primary malignancy in the endometrium was diagnosed (146 within 1 year). The ratio of observed versus expected number of synchronous malignancy in the endometrium was estimated at 3.6 (95% CI: 2.7-4.7). Among 460 ovarian endometrioid carcinoma patients 53 cases showed a second primary endometrial cancer; 40 out of these 53 cases (75.5%) showed at both organ sites an endometrioid adenocarcinoma. Conclusion. These findings suggest an important role for the endometrioid subtype and prompt to mechanism-based studies incorporating molecular techniques.
目的。卵巢癌和子宫内膜癌在同一患者中相当常见。关于特定形态学亚型受累的数据很少。为了确定同步发生中的组织学途径，在荷兰进行了一项基于人群的研究。方法。利用国家病理学数据库（PALGA）获取卵巢癌以及子宫内膜早期或晚期癌症的信息。共识别出5366例原发性恶性上皮性或交界性恶性肿瘤患者。结果。在157例（2.9%）患者中诊断出子宫内膜新的原发性恶性肿瘤（146例在1年内）。子宫内膜同步恶性肿瘤的观察数与预期数之比估计为3.6（95%可信区间：2.7 - 4.7）。在460例卵巢子宫内膜样癌患者中，53例出现了第二原发性子宫内膜癌；这53例中的40例（75.5%）在两个器官部位均表现为子宫内膜样腺癌。结论。这些发现表明子宫内膜样亚型起重要作用，并促使开展结合分子技术的基于机制的研究。
