Sadidi Hossein, Izadi-Mood Narges, Sarmadi Soheila, Yarandi Fariba, Amini-Moghaddam Soheila, Esfahani Fatemeh, Sadidi Mohammad
Research Development Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathology, Women Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2015 Aug;20(8):727-32. doi: 10.4103/1735-1995.168315.
The coexistence primary cancers of the endometrium and ovary are relatively uncommon. The purpose of this study was to characterize patients diagnosed primary synchronous endometrial and ovarian cancer (SEOC), endometrial cancer (EC) with ovarian metastasis, and ovarian cancer (OC) with endometrial metastasis and compare clinicopathologic variables and prognosis.
All the patients with diagnosis of both endometrium and OC, who hospitalized between 2002 and 2012 in an academic center affiliated to Tehran University of Medical Sciences, were evaluated with respect to different clinicopathologic variables, follow-up times, and outcomes.
Fifty-five patients had been diagnosed with both endometrium and OC. 17, 26, and 12 patients were diagnosed as SEOC, EC, and OC, respectively. The frequency of abnormal uterine bleeding was significantly lower in OC (16.7%) compared to others (58.8% in SEOC and 53.8% in EC). However, the abdominal/pelvic pain was significantly higher in OC (50%) compared to others (35.3% in SEOC and 34.6% in EC) (P < 0.05). Complex atypical hyperplasia (87.5%), endometriosis (88.8%), and endometrioid carcinoma (54.5%) was observed most in SEOC group. The duration of follow-up time was between 3 and 171 months with a mean of 16 months. There was no death in SEOC who followed. Survivals of patients between three group were statistically significant (P = 0.032).
Our results showed that overall survival (OS) and progression-free survival (PFS) of SEOC patients is better than those with EC and OC (P = 0.032).
子宫内膜和卵巢同时存在原发性癌症相对少见。本研究的目的是对诊断为原发性同步子宫内膜和卵巢癌（SEOC）、伴有卵巢转移的子宫内膜癌（EC）以及伴有子宫内膜转移的卵巢癌（OC）的患者进行特征描述，并比较临床病理变量和预后。
对2002年至2012年在德黑兰医科大学附属学术中心住院的所有诊断为子宫内膜和OC的患者，就不同的临床病理变量、随访时间和结局进行评估。
55例患者被诊断为同时患有子宫内膜和OC。分别有17例、26例和12例患者被诊断为SEOC、EC和OC。与其他组（SEOC中为58.8%，EC中为53.8%）相比，OC中异常子宫出血的发生率显著更低（16.7%）。然而，与其他组（SEOC中为35.3%，EC中为34.6%）相比，OC中腹部/盆腔疼痛的发生率显著更高（50%）（P < 0.05）。在SEOC组中，复杂非典型增生（87.5%）、子宫内膜异位症（88.8%）和子宫内膜样癌（54.5%）最为常见。随访时间为3至171个月，平均为16个月。随访的SEOC患者中无死亡病例。三组患者的生存率具有统计学意义（P = 0.032）。
我们的结果表明，SEOC患者的总生存期（OS）和无进展生存期（PFS）优于EC和OC患者（P = 0.032）。
