Department of Oncologic Gynecology, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Taleghani Hospital, Arak University of Medical Sciences, Arak, Iran.
J Ovarian Res. 2021 Dec 7;14(1):171. doi: 10.1186/s13048-021-00925-7.
Epithelial ovarian cancer (EOC) is an extremely aggressive and lethal carcinoma. Specific data that identify high-risk groups with uterine involvement are not available. Thus, this study aimed to evaluate a gross number of women with EOC to obtain the frequency of uterine involvement and its risk factors.
This retrospective observational study was conducted on 1900 histologically confirmed EOC women, diagnosed and treated in our tertiary hospital from March 2009 to September 2020. Data including their demographic, medical and pathological findings were collected.
From 1900 histologically confirmed EOC women, 347 patients were eligible for participations. The mean age of study patients was 51.31 ± 11.37 years with the age range of 25 to 87 years. Uterine involvement was detected in 49.6% (173) of the patients either macroscopic (47.4%) or microscopic (52.6%) types. Uterine involvement was significantly associated with having AUB (P-value = 0.002), histological type of ovary tumor (P-value < 0.001), ovarian cancer stage (P-value < 0.001), and abnormal CA-125 concentration (P-value = 0.004). Compared to the other study patient, the patients with metastatic uterine involvement had significantly higher stage (p-value< 0.001), higher grade of ovary tumor (p-value = 0.008), serous histological type (p-value< 0.001), and a higher level of CA-125 concentration (p-value< 0.001). on the other hand, the patients with synchronous uterine cancer were significantly younger (p-value = 0.013), nulliparous (p-value< 0.001), suffered from AUB symptoms (p-value< 0.001) and had endometroid histological type (p-value = 0.010) of ovary cancer in comparison to other study patients.
Considering the high prevalence of uterine involvement in EOC patients, ultrasound evaluation and/or endometrium biopsy assessment should be done before planning any treatment.
上皮性卵巢癌（EOC）是一种极具侵袭性和致命性的癌。目前尚无明确的特定数据来识别存在子宫受累的高危人群。因此，本研究旨在评估大量患有 EOC 的女性，以获得子宫受累的频率及其危险因素。
本回顾性观察性研究纳入了 1900 例 2009 年 3 月至 2020 年 9 月在我院经组织学确诊的上皮性卵巢癌女性患者，收集其人口统计学、临床和病理数据。
在 1900 例经组织学确诊的 EOC 女性患者中，有 347 例符合入组条件。研究患者的平均年龄为 51.31±11.37 岁，年龄范围为 25 至 87 岁。49.6%（173 例）的患者存在子宫受累，包括肉眼可见（47.4%）或镜下可见（52.6%）的类型。子宫受累与异常子宫出血（AUB）（P 值=0.002）、卵巢肿瘤的组织学类型（P 值<0.001）、卵巢癌分期（P 值<0.001）和异常 CA-125 浓度（P 值=0.004）显著相关。与其他研究患者相比，转移性子宫受累患者的分期显著更高（p 值<0.001），卵巢肿瘤分级更高（p 值=0.008），组织学类型为浆液性（p 值<0.001），CA-125 浓度更高（p 值<0.001）。另一方面，与其他研究患者相比，同时患有子宫癌的患者显著更年轻（p 值=0.013）、未生育（p 值<0.001）、患有 AUB 症状（p 值<0.001）和卵巢癌的组织学类型为子宫内膜样（p 值=0.010）。
鉴于 EOC 患者子宫受累的高发生率，在制定任何治疗方案之前，应进行超声评估和/或子宫内膜活检评估。
