Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea.
J Korean Med Sci. 2010 Jan;25(1):83-9. doi: 10.3346/jkms.2010.25.1.83. Epub 2009 Dec 26.
We investigated the vitamin D status and the effect of vitamin D supplementation in Korean breast-fed infants. The healthy term newborns were divided into 3 groups; A, formula-fed; B, breast-fed only; S, breast-fed with vitamin D supplementation. We measured serum concentrations of vitamin D (25OHD3), calcium (Ca), phosphorus (P), alkaline phosphatase (AP), intact parathyroid hormone (iPTH) and bone mineral density (BMD) at 6 and 12 months of age. Using questionnaires, average duration of sun-light exposure and dietary intake of vitamin D, Ca and P were obtained. At 6 and 12 months of age, 25OHD3 was significantly higher in group S than in group B (P<0.001). iPTH was significantly lower in group S than in group B at 6 months (P=0.001), but did not differ at 12 months. Regardless of vitamin D supplementation, BMD was lower in group B and S than in group A (P<0.05). Total intake of vitamin D differed among 3 groups (P<0.001, A>S>B), but total intake of Ca and P were higher in group A than in group B and S (P<0.001). In conclusion, breast-fed infants show lower vitamin D status and bone mineralization than formula-fed infants. Vitamin D supplementation (200 IU/day) in breast-fed infants increases serum 25-OH vitamin D(3), but not bone mineral density.
我们研究了维生素 D 状况以及维生素 D 补充对韩国母乳喂养婴儿的影响。将健康足月新生儿分为 3 组；A 组，配方奶喂养；B 组，纯母乳喂养；S 组，母乳喂养加维生素 D 补充。我们测量了血清维生素 D（25OHD3）、钙（Ca）、磷（P）、碱性磷酸酶（AP）、完整甲状旁腺激素（iPTH）和骨矿物质密度（BMD）在 6 个月和 12 个月时的浓度。通过问卷调查，获得平均阳光暴露时间和维生素 D、Ca 和 P 的饮食摄入量。在 6 个月和 12 个月时，S 组的 25OHD3 明显高于 B 组（P<0.001）。S 组的 iPTH 在 6 个月时明显低于 B 组（P=0.001），但在 12 个月时没有差异。无论是否补充维生素 D，B 组和 S 组的 BMD 均低于 A 组（P<0.05）。3 组间维生素 D 总摄入量存在差异（P<0.001，A>S>B），但 A 组的 Ca 和 P 总摄入量高于 B 组和 S 组（P<0.001）。总之，母乳喂养的婴儿维生素 D 状态和骨矿物质化程度低于配方奶喂养的婴儿。在母乳喂养的婴儿中补充维生素 D（200 IU/天）可增加血清 25-OH 维生素 D（3），但不能增加骨矿物质密度。
