酿酒酵母MMS敏感突变体中自发有丝分裂分离增加。
Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae.
作者信息
Prakash S, Prakash L
出版信息
Genetics. 1977 Oct;87(2):229-36. doi: 10.1093/genetics/87.2.229.
Abstract
Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13-to 170-fold. The mms8-1 mutant is MMS and X-ray sensitive and increases the rate of spontaneous mitotic segregation 170-fold. The mms9-1 and mms13-1 mutants are sensitive to X rays and UV, respectively, in addition of MMS, and increase the rate of spontaneous mitotic segregation by 13-fold and 85-fold, respectively. The mutant mms21-1 is sensitive to MMS, X rays and UV and increases the rate of spontaneous mitotic segregation 23-fold.
摘要
酿酒酵母的甲磺酸甲酯（MMS）敏感突变体属于四个不同的互补组，纯合时，杂合敏感（canr/+）二倍体自发有丝分裂分离到刀豆氨酸抗性的速率提高了13至170倍。mms8-1突变体对MMS和X射线敏感，自发有丝分裂分离速率提高了170倍。mms9-1和mms13-1突变体除了对MMS敏感外，分别对X射线和紫外线敏感，自发有丝分裂分离速率分别提高了13倍和85倍。突变体mms21-1对MMS、X射线和紫外线敏感，自发有丝分裂分离速率提高了23倍。
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