Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Chem Asian J. 2010 Mar 1;5(3):386-96. doi: 10.1002/asia.200900512.
The rhodium-catalyzed conjugate addition of organoboron reagents to alkene acceptors has emerged as an important methodology in organic synthesis. The process results in the formation of new carbon-carbon bonds, and in principle, can create new stereocenters at both the alpha and beta carbon atoms of the acceptor. Other organometallics are known to participate in the key transmetalation to rhodium and are becoming more established in stereoselective synthesis (notably arylzinc reagents). This Focus Review will describe recent developments in the use of alternative organometallic donors to organoboron reagents in rhodium-catalyzed conjugate addition reactions and their growing applications in synthesis.
铑催化的有机硼试剂与烯烃受体的共轭加成已成为有机合成中的一种重要方法。该过程导致新的碳-碳键的形成，并且原则上可以在受体的α和β碳原子处创建新的立体中心。已知其他有机金属化合物参与关键的向铑的转金属化，并且在立体选择性合成中变得更加成熟（特别是芳基锌试剂）。本重点综述将描述在铑催化的共轭加成反应中使用替代有机金属供体代替有机硼试剂的最新发展，以及它们在合成中的应用不断增加。
