木霉属真菌合成抗肿瘤酶L-赖氨酸-α-氧化酶

[Biosynthesis of L-lysine-alpha-oxidase, an antitumor enzyme, by Trichoderma spp].

作者信息

Smirnova I P, Alekseev S B, Shevchenko A A

出版信息

Antibiot Khimioter. 2009;54(5-6):8-12.

Abstract

Strains of Trichoderma spp., producing L-lysine-alpha-oxidase, prospective in chemotherapy of malignant tumors, were studied. The best results of the enzyme biosynthesis were observed on the wheat bran medium. When grown on the media with various pH levels, the strains showed different spectra of the L-aminooxidase activity. The highest activity of the strains was recorded with respect to destruction of L-lysine. The lysine-producing organism Brevibacterium sp. induced L-lysine-alpha-oxidase activity in Trichoderma spp.

摘要

对产生L-赖氨酸-α-氧化酶、有望用于恶性肿瘤化疗的木霉属菌株进行了研究。在麦麸培养基上观察到了该酶生物合成的最佳结果。当在不同pH值的培养基上生长时，这些菌株表现出不同的L-氨基酸氧化酶活性谱。就L-赖氨酸的降解而言，记录到这些菌株的活性最高。产赖氨酸的短杆菌属菌株可诱导木霉属菌株中的L-赖氨酸-α-氧化酶活性。

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