Smirnova I P, Karimova E V, Shneider Yu A
T. T. Berezov Department of Biochemistry, Medical Faculty of the Medical Institute, the Peoples' Friendship University of Russia, Moscow, Russia.
Bull Exp Biol Med. 2017 Oct;163(6):777-779. doi: 10.1007/s10517-017-3901-0. Epub 2017 Oct 24.
We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system of G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences (Pushchino). Activity of L-lysine-α-oxidase in the prepared concentrate of metabolic products of the producer was 5.4 U/ml, and activity of the homogenous enzyme was 50 U/ml. Antibacterial activity of the enzyme was shown in our experiments.
我们研究了哈茨木霉里氏木霉F-180（L-赖氨酸-α-氧化酶的活性产生菌）代谢产物浓缩物及纯酶对高致病性细菌梨火疫病菌的影响。抗肿瘤和抗病毒的木霉L-赖氨酸-α-氧化酶产生菌在俄罗斯科学院微生物生物化学与生理学研究所（普希诺）的G.K.斯克里亚宾加工系统中培养。制备的产生菌代谢产物浓缩物中L-赖氨酸-α-氧化酶的活性为5.4 U/ml，纯酶的活性为50 U/ml。我们的实验显示了该酶的抗菌活性。
