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经心肌激光血运重建术

[Transmyocardial laser revascularization].

作者信息

Urban M, Pirk J, Szárszoi O, Vodicková J, Netuka I

机构信息

Klinika kardiovaskulární chirurgie IKEM, Praha 4.

出版信息

Rozhl Chir. 2009 Sep;88(9):489-92.

Abstract

AIM OF THE STUDY

The study looked at our results with transmyocardial laser revascularization. We also tried to ascertain the role of TMLR in current cardiothoracic surgical practice.

METHODS

Twenty patients underwent TMLR at IKEM Praha in a period from 1999 to 2007. Patients were categorized into two separate groups. The first included patients who had TMLR as a single procedure. Second group comprised patients who underwent combined TMLR and direct bypass revascularization. Outcome measures were reduction of angina, improvements in exercise tolerance and left ventricular systolic function.

RESULTS

Improvement in CCS classification of two and more classes has been achieved in almost half the patients who underwent TMLR combined with CABG, but only in 20% of patients after isolated TMLR. There was no change in left ventricular systolic function either in group of patients after TMLR or in group with hybrid procedure. There was also no change detected in myocardial perfusion in thallium scintigraphy studies.

CONCLUSION

The study confirmed that TMLR has minimal perioperative complication rate and is safe. On the other hand our results failed to demonstrate any significant improvement in quality of life following TMLR. In our opinion TMLR should be reserved for symptomatic patients in CCS IV class when all other conventional treatment options have been exhausted.

摘要

研究目的

本研究观察了经心肌激光血运重建术的结果。我们还试图确定经心肌激光血运重建术在当前心胸外科手术实践中的作用。

方法

1999年至2007年期间,20例患者在布拉格IKEM接受了经心肌激光血运重建术。患者被分为两个独立的组。第一组包括接受单纯经心肌激光血运重建术的患者。第二组包括接受经心肌激光血运重建术与直接旁路血运重建术联合手术的患者。观察指标为心绞痛减轻、运动耐量改善和左心室收缩功能改善。

结果

接受经心肌激光血运重建术联合冠状动脉旁路移植术的患者中,几乎一半患者的加拿大心血管学会(CCS)分级改善了两级或两级以上,但单纯经心肌激光血运重建术后的患者中只有20%改善。经心肌激光血运重建术组或杂交手术组患者的左心室收缩功能均无变化。铊闪烁显像研究中也未检测到心肌灌注有变化。

结论

该研究证实经心肌激光血运重建术围手术期并发症发生率极低且安全。另一方面,我们的结果未能证明经心肌激光血运重建术后生活质量有任何显著改善。我们认为,当所有其他传统治疗方案均已用尽时,经心肌激光血运重建术应保留用于加拿大心血管学会IV级有症状的患者。

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