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采用马尔可夫模拟模型评估冠心病发病率变化趋势对西澳大利亚州冠状动脉血运重建术需求的影响。

Using a Markov simulation model to assess the impact of changing trends in coronary heart disease incidence on requirements for coronary artery revascularization procedures in Western Australia.

机构信息

Department of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

出版信息

BMC Cardiovasc Disord. 2010 Jan 6;10:2. doi: 10.1186/1471-2261-10-2.

Abstract

BACKGROUND

The population incidence of coronary heart disease (CHD) has been declining in Australia and many other countries. This decline has been due to reduced population levels of risk factors for CHD and improved medical care for those at higher risk of CHD. However, there are signs that there may be a slowing down or even reversal in the decline of CHD incidence due to the 'obesity epidemic' and other factors and this will have implications for the requirements for surgical treatments for those with CHD.

METHODS

Using a validated Markov simulation model applied to the population of Western Australia, different CHD incidence trend scenarios were developed to explore the effect of changing CHD incidence on requirements for coronary artery bypass graft (CABG) and percutaneous coronary interventions (PCI), together known as coronary artery revascularization procedures (CARPs).

RESULTS

The most dominant component of CHD incidence is the risk of CHD hospital admission for those with no history of CHD and if this risk leveled off and the trends in all other risks continued unchanged, then the projected numbers of CABGs and PCIs are only minimally changed. Further, the changes in the projected numbers remained small even when this risk was increased by 20 percent (although it is an unlikely scenario). However, when the other CHD incidence components that had also been declining, namely, the risk of CABG and that of CHD death for those with no history of CHD, were also projected to level off as these were declining in 1998-2000 and the risk of PCI for those with no history of CHD (which was already increasing) was projected to further increase by 5 percent, it had a substantial effect on the projected numbers of CARPs.

CONCLUSION

There needs to be dramatic changes to several CHD incidence components before it has a substantial impact on the projected requirements for CARPs. Continued monitoring of CHD incidence and also the mix of initial presentation of CHD incidence is required in order to understand changes to future CARP requirements.

摘要

背景

在澳大利亚和许多其他国家,冠心病(CHD)的人群发病率一直在下降。这种下降归因于 CHD 风险因素的人群水平降低和对 CHD 高危人群的医疗改善。然而,有迹象表明,由于“肥胖流行”和其他因素,CHD 发病率的下降可能正在放缓甚至逆转,这将对 CHD 患者手术治疗的需求产生影响。

方法

使用针对西澳大利亚人口的经过验证的马尔可夫模拟模型,制定了不同的 CHD 发病率趋势情景,以探讨 CHD 发病率变化对冠状动脉旁路移植术(CABG)和经皮冠状动脉介入治疗(PCI)(统称为冠状动脉血运重建程序(CARPs))需求的影响。

结果

CHD 发病率的最主要组成部分是无 CHD 病史人群的 CHD 住院风险,如果该风险水平稳定,且所有其他风险的趋势保持不变,那么预计的 CABG 和 PCI 数量仅略有变化。此外,即使将该风险增加 20%(尽管不太可能),预计的数量变化也仍然很小。然而,当其他 CHD 发病率组成部分(即无 CHD 病史人群的 CABG 风险和 CHD 死亡风险)也预计会像 1998-2000 年那样下降,而无 CHD 病史人群的 PCI 风险(已经在增加)预计会进一步增加 5%时,这对 CARP 的预计数量产生了重大影响。

结论

在对 CARP 的预计需求产生重大影响之前,需要对几个 CHD 发病率组成部分进行重大改变。需要继续监测 CHD 发病率,以及 CHD 发病率的初始表现组合,以便了解未来 CARP 需求的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cc/2824688/17a3683d9cda/1471-2261-10-2-1.jpg

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