Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Curr Opin Microbiol. 2010 Feb;13(1):59-66. doi: 10.1016/j.mib.2009.12.008. Epub 2010 Jan 5.
The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4. AnkA is highly tyrosine phosphorylated and binds to the Abl interactor 1, SHP-1, and nuclear DNA fragments. Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus. The recent discovery of several ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bacteria suggests that a common strategy evolved to subvert host-cell functions.
必须在细胞内寄生的细菌病原体嗜吞噬细胞无形体和埃立克体通过劫持宿主细胞成分和过程感染白细胞。在感染过程中，IV 型分泌系统被上调。在 IV 型分泌候选底物中，嗜吞噬细胞无形体的锚蛋白重复蛋白 AnkA 通过包含 VirD4 的复合物被递送到宿主细胞质中。AnkA 高度酪氨酸磷酸化，并与 Abl 相互作用蛋白 1（SHP-1）和核 DNA 片段结合。最近有报道称，埃立克体属的 Chaffeensis 无形体 AnkA 被转位到宿主细胞的核内。最近发现几种通过不同的细胞内细菌的 IV 型分泌系统分泌的锚蛋白重复蛋白，表明进化出一种共同的策略来颠覆宿主细胞的功能。
