用 RNAi 筛选技术鉴定调控秀丽隐杆线虫衰老的基因网络组件。
RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans.
机构信息
Cornell University, Ithaca, NY 14853, USA.
出版信息
Brief Funct Genomics. 2010 Jan;9(1):53-64. doi: 10.1093/bfgp/elp051. Epub 2010 Jan 6.
Abstract
Our understanding of the genetic mechanisms of organismal aging has advanced dramatically during the past two decades. With the development of large-scale RNAi screens, the last few years saw the remarkable identifications of hundreds of new longevity genes in the roundworm Caenorhabditis elegans. The various RNAi screens revealed many biological pathways previously unknown to be related to aging. In this review, we focus on findings from the recent large-scale RNAi longevity screens, and discuss insights they have provided into the complex biological process of aging and considerations of the RNAi technology will continue to have on the future development of the aging field.
摘要
在过去的二十年中，我们对生物体衰老的遗传机制的理解有了显著的进步。随着大规模 RNAi 筛选技术的发展，在过去的几年中，在秀丽隐杆线虫中发现了数百个新的长寿基因。各种 RNAi 筛选揭示了许多以前未知与衰老有关的生物途径。在这篇综述中，我们重点介绍了最近大规模 RNAi 寿命筛选的发现，并讨论了它们为衰老这一复杂的生物学过程提供的新见解，以及 RNAi 技术将如何继续影响衰老领域的未来发展。
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