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本文引用的文献

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.4E-BP通过增强果蝇的线粒体活性，在饮食限制条件下延长寿命。
Cell. 2009 Oct 2;139(1):149-60. doi: 10.1016/j.cell.2009.07.034.
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Caloric restriction delays disease onset and mortality in rhesus monkeys.热量限制可延缓恒河猴疾病的发作和死亡。
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
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Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection.全基因组RNA干扰筛选鉴定出参与肠道致病性细菌感染的基因。
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A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans.秀丽隐杆线虫对呼吸受损的调节反应会减缓行为速率并延长寿命。
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A human protein interaction network shows conservation of aging processes between human and invertebrate species.一个人类蛋白质相互作用网络显示了人类和无脊椎动物物种之间衰老过程的保守性。
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A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.一种PP2A调节亚基通过调节AKT-1磷酸化来调控秀丽隐杆线虫的胰岛素/IGF-1信号通路。
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Association of FOXO3A variation with human longevity confirmed in German centenarians.FOXO3A基因变异与人类长寿之间的关联在德国百岁老人中得到证实。
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Export of RNA silencing from C. elegans tissues does not require the RNA channel SID-1.秀丽隐杆线虫组织中RNA沉默的输出不需要RNA通道SID-1。
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Insulin/IGF-like signalling, the central nervous system and aging.胰岛素/胰岛素样生长因子信号通路、中枢神经系统与衰老
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用 RNAi 筛选技术鉴定调控秀丽隐杆线虫衰老的基因网络组件。

RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans.

机构信息

Cornell University, Ithaca, NY 14853, USA.

出版信息

Brief Funct Genomics. 2010 Jan;9(1):53-64. doi: 10.1093/bfgp/elp051. Epub 2010 Jan 6.

DOI:10.1093/bfgp/elp051
PMID:20053814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3096447/
Abstract

Our understanding of the genetic mechanisms of organismal aging has advanced dramatically during the past two decades. With the development of large-scale RNAi screens, the last few years saw the remarkable identifications of hundreds of new longevity genes in the roundworm Caenorhabditis elegans. The various RNAi screens revealed many biological pathways previously unknown to be related to aging. In this review, we focus on findings from the recent large-scale RNAi longevity screens, and discuss insights they have provided into the complex biological process of aging and considerations of the RNAi technology will continue to have on the future development of the aging field.

摘要

在过去的二十年中，我们对生物体衰老的遗传机制的理解有了显著的进步。随着大规模 RNAi 筛选技术的发展，在过去的几年中，在秀丽隐杆线虫中发现了数百个新的长寿基因。各种 RNAi 筛选揭示了许多以前未知与衰老有关的生物途径。在这篇综述中，我们重点介绍了最近大规模 RNAi 寿命筛选的发现，并讨论了它们为衰老这一复杂的生物学过程提供的新见解，以及 RNAi 技术将如何继续影响衰老领域的未来发展。