Lee Siu Sylvia
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Exp Gerontol. 2006 Oct;41(10):968-73. doi: 10.1016/j.exger.2006.06.048. Epub 2006 Aug 7.
This article discusses the pros and cons of using RNAi screening to identify longevity genes in Caenorhabditis elegans. The discussion will focus on the results of two large-scale longevity RNAi screens that were recently published. The two screens revealed largely non-overlapping sets of candidate longevity genes. The possible reasons for such differences and their implications will be discussed.
本文讨论了利用RNA干扰筛选来鉴定秀丽隐杆线虫中长寿基因的利弊。讨论将聚焦于最近发表的两项大规模长寿RNA干扰筛选的结果。这两项筛选揭示了大量不重叠的候选长寿基因集。将讨论产生这种差异的可能原因及其影响。
