Ulich T R, Guo K Z, Remick D, del Castillo J, Yin S M
Department of Pathology, UC Irvine School of Medicine 92717.
J Immunol. 1991 Apr 1;146(7):2316-23.
Endotoxin (LPS) at sublethal doses injected i.v. into rats was found to induce IL-6 mRNA expression peaking at 1 to 2 h in whole organ RNA preparations of the spleen, liver, lung, bowel, and kidney. IL-6 serum protein levels also peaked at 2 h. TNF and IL-1, generally considered to be among the most rapidly released cytokines, also induced IL-6 expression. IL-6 in turn inhibited TNF and IL-1 expression, suggesting that IL-6 may be part of a negative feedback mechanism in the cytokine cascade. Dexamethasone down-regulated and Corynebacterium parvum up-regulated IL-6 expression, although the possibility cannot be excluded that these immunomodulating factors may in part have exerted their effects indirectly via the up- and down-regulation of TNF and IL-1. IL-6 injected i.v. at a pathophysiologically relevant dose caused a peripheral neutrophilia and mild myeloproliferative effect in the bone marrow.
静脉注射亚致死剂量的内毒素（脂多糖）到大鼠体内后，发现脾脏、肝脏、肺、肠道和肾脏的全器官RNA制剂中，白细胞介素-6（IL-6）mRNA表达在1至2小时达到峰值。血清IL-6蛋白水平也在2小时达到峰值。通常被认为是释放速度最快的细胞因子之一的肿瘤坏死因子（TNF）和白细胞介素-1（IL-1），也诱导了IL-6的表达。IL-6反过来抑制TNF和IL-1的表达，这表明IL-6可能是细胞因子级联反应中负反馈机制的一部分。地塞米松下调而短小棒状杆菌上调IL-6的表达，尽管不能排除这些免疫调节因子可能部分通过TNF和IL-1的上调和下调间接发挥作用的可能性。以病理生理学相关剂量静脉注射IL-6会导致外周血中性粒细胞增多以及骨髓出现轻度骨髓增殖效应。
