类风湿关节炎患者血清中MCP-1表达水平与间质性肺病的关系

[Relationship between the level of MCP-1 expression in sera of RA patients and ILD].

作者信息

Ling Tao, Lv Hao-Zhe, Ma Yu-Xia, Shang Qing-Hui, Zhang Jin-Tao, Lu Jing

机构信息

Department of Rheumatology and Immunology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.

出版信息

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jan;26(1):59-60.

PMID:20056091

Abstract

AIM

To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis(RA)and the relation ship between the expression of MCP-1 in serum and interstitial lung disease (ILD) secondary from RA.

METHODS

60 patients with RA were divided into two groups: 30 cases with simple RA group and 30 cases with ILD secondary from RA (RA+ILD group). The control group incuided 20 healthy cases. Enzyme linked immunosorbent assay (ELISA ) was used to determine the serum expression of MCP-1 in patients healthy controls. The differences of MCP-1 level and other laboratory indexes (IgG, IgA, IgM, alpha2-G, gamma-G, RF, ESR, CRP, and the number of arthrocele) in different groups were compared with software spss13.0.

RESULTS

The expression of MCP-1 in simple RA patients was significantly higher than that in the control group (P>0.05) and significantly lower than that in the RA+ILD group (P>0.01). The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G.

CONCLUSION

MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.

摘要

目的

探讨单核细胞趋化蛋白-1（MCP-1）在类风湿关节炎（RA）发病机制中的作用及临床意义，以及血清中MCP-1表达与RA继发间质性肺病（ILD）的关系。

方法

将60例RA患者分为两组：单纯RA组30例和RA继发ILD组（RA+ILD组）30例。对照组包括20例健康者。采用酶联免疫吸附测定（ELISA）法检测患者及健康对照者血清中MCP-1的表达。运用spss13.0软件比较不同组间MCP-1水平及其他实验室指标（IgG、IgA、IgM、α2-G、γ-G、RF、ESR、CRP及关节腔积液数量）的差异。