Graduate Institute of Natural Products, Kaohsiung Medical University 807, Taiwan, ROC.
Bioorg Med Chem. 2010 Jan 15;18(2):518-25. doi: 10.1016/j.bmc.2009.12.016. Epub 2009 Dec 11.
Eight new lignin derivatives, termed quiquelignan A-H (1-8), comprising three tricin-type flavonolignans (1-3) and five 8-O-4' neolignans (4-8), were isolated from the ethanol extract of Calamus quiquesetinervius stems. Structural elucidation of the new isolates was accomplished on the basis of spectroscopic data. Compounds 1-8 showed strong-to-moderate antioxidant activity against the hydroxy radical (()OH). Among them, compound 5 showed significantly higher hydroxy radical scavenging activity (IC(50) 4.4microg/mL). Compounds 2-4 and 6-8 dose-dependently suppressed the LPS-stimulated production of nitric oxide (NO) in RAW 264.7 cells. The anti-inflammatory potency of 4 and 6 was 2.7-4.5-fold higher compared with quercetin. Compounds 2-4, 6 and 8 also exhibited mild collagen-antagonistic activity, but were inactive with respect to thrombin-induced platelet aggregation.
从 Calamus quiquesetinervius 茎的乙醇提取物中分离得到了 8 种新的木质素衍生物，称为 quiquelignan A-H（1-8），包括 3 种三嗪型黄酮木脂素（1-3）和 5 种 8-O-4'新木脂素（4-8）。根据光谱数据对新分离物的结构进行了阐明。化合物 1-8 对羟基自由基（()OH）显示出强至中等的抗氧化活性。其中，化合物 5 对羟基自由基的清除活性显著较高（IC（50）为 4.4μg/mL）。化合物 2-4 和 6-8 剂量依赖性地抑制 RAW 264.7 细胞中 LPS 刺激的一氧化氮（NO）的产生。与槲皮素相比，4 和 6 的抗炎效力高 2.7-4.5 倍。化合物 2-4、6 和 8 还表现出轻微的胶原拮抗活性，但对凝血酶诱导的血小板聚集没有活性。
