Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati, India.
Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, India.
Phytother Res. 2022 May;36(5):1884-1913. doi: 10.1002/ptr.7408. Epub 2022 Feb 11.
Thrombotic complications occur in many cardiovascular pathologies and have been demonstrated in COVID-19. The currently used antithrombotic drugs are not free of adverse reactions, and COVID-19 patients in particular, when treated with a therapeutic dose of an anticoagulant do not receive mortality benefits. The clinical management of COVID-19 is one of the most difficult tasks for clinicians, and the search for safe, potent, and effective antithrombotic drugs may benefit from exploring naturally bioactive molecules from plant sources. This review describes recent advances in understanding the antithrombotic potential of herbal drug prototypes and points to their future clinical use as potent antithrombotic drugs. Although natural products are perceived to be safe, their clinical and therapeutic applications are not always apparent or accepted. More in-depth studies are necessary to demonstrate the clinical usefulness of plant-derived, bioactive compounds. In addition, holistic approaches in systematic investigations and the identification of antithrombotic mechanisms of the herbal bioactive molecule(s) need to be conducted in pre-clinical studies. Moreover, rigorous studies are needed to compare the potency of herbal drugs to that of competitor chemical antithrombotic drugs, and to examine their interactions with Western antithrombotic medicines. We have also proposed a road map to improve the commercialization of phytopharmaceuticals.
血栓并发症发生在许多心血管疾病中，并已在 COVID-19 中得到证实。目前使用的抗血栓药物并非没有不良反应，尤其是 COVID-19 患者，当用治疗剂量的抗凝剂治疗时，并未获得死亡率的益处。COVID-19 的临床管理是临床医生面临的最艰巨任务之一，寻找安全、有效、有效的抗血栓药物可能需要从植物来源的天然生物活性分子中进行探索。这篇综述描述了最近在理解草药药物原型的抗血栓潜力方面的进展，并指出它们未来可能作为有效的抗血栓药物在临床上的应用。尽管天然产物被认为是安全的，但它们的临床和治疗应用并不总是明显或被接受。需要进行更深入的研究来证明植物来源的生物活性化合物的临床实用性。此外，还需要在临床前研究中进行系统研究和鉴定草药生物活性分子的抗血栓机制的整体方法。此外，还需要进行严格的研究来比较草药药物的效力与竞争化学抗血栓药物的效力，并研究它们与西方抗血栓药物的相互作用。我们还提出了改善植物药物商业化的路线图。
