心肌成纤维细胞-心肌细胞通讯。
Intramyocardial fibroblast myocyte communication.
机构信息
Cardiology Division, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
出版信息
Circ Res. 2010 Jan 8;106(1):47-57. doi: 10.1161/CIRCRESAHA.109.207456.
Abstract
Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in extracellular matrix homeostasis, and direct cell-cell interactions. It is possible that they are a contributor to the inability of adult myocytes to proliferate and may influence cardiac progenitor biology. Furthering our understanding of how cardiac fibroblasts and myocytes interact may provide an avenue to novel treatments for heart failure prevention. This review discusses the most recent concepts in cardiac fibroblast-myocyte communication and areas of potential future research.
摘要
心脏成纤维细胞作为正常心脏功能以及对应激和损伤反应的关键组成部分正在逐渐显现。这些心脏中数量最多的细胞通过旁分泌机制、细胞外基质稳态的改变以及直接的细胞-细胞相互作用与心肌细胞相互作用。它们可能是成年心肌细胞不能增殖的原因之一，并可能影响心脏祖细胞生物学。进一步了解心脏成纤维细胞和心肌细胞如何相互作用可能为预防心力衰竭的新治疗方法提供途径。本文讨论了心脏成纤维细胞-心肌细胞通讯的最新概念和潜在的未来研究领域。
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