Wang Mengmeng, Mo Degang, Zhang Ning, Yu Haichu
Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Heliyon. 2024 Jul 28;10(15):e35219. doi: 10.1016/j.heliyon.2024.e35219. eCollection 2024 Aug 15.
Diabetic cardiomyopathy (DCM) is a common complication of diabetes, and its pathogenesis remains elusive. Ferroptosis, a process dependent on iron-mediated cell death, plays a crucial role in DCM via disrupted iron metabolism, lipid peroxidation, and weakened antioxidant defenses. Hyperglycemia, oxidative stress, and inflammation may exacerbate ferroptosis in diabetes. This review emphasizes the interaction between cardiac fibroblasts and cardiomyocytes in DCM, influencing ferroptosis occurrence. By exploring ferroptosis modulation for potential therapeutic targets, this article offers a fresh perspective on DCM treatment. The study systematically covers the interplay, mechanisms, and targeted drugs linked to ferroptosis in DCM development.
糖尿病性心肌病（DCM）是糖尿病常见的并发症，其发病机制仍不明确。铁死亡是一种依赖铁介导的细胞死亡过程，通过破坏铁代谢、脂质过氧化和削弱抗氧化防御在DCM中起关键作用。高血糖、氧化应激和炎症可能会加剧糖尿病中的铁死亡。本综述强调了DCM中心脏成纤维细胞与心肌细胞之间的相互作用，这种相互作用会影响铁死亡的发生。通过探索针对潜在治疗靶点的铁死亡调节，本文为DCM治疗提供了新的视角。该研究系统地涵盖了与DCM发展中铁死亡相关的相互作用、机制和靶向药物。
