Institute of Cardiovascular Sciences University of Birmingham United Kingdom.
Division of Cardiovascular Medicine Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford University of Oxford United Kingdom.
J Am Heart Assoc. 2021 Feb;10(5):e019338. doi: 10.1161/JAHA.120.019338. Epub 2021 Feb 15.
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast-to-myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.
心肌成纤维细胞是心脏细胞外基质沉积的主要细胞类型，为收缩心肌提供支持，并参与多种生理信号过程。尽管纤维化在伤口愈合过程中很重要，但成纤维细胞过度增殖和激活会导致病理性重构，导致心力衰竭和心律失常的发生。我们对驱动心肌成纤维细胞激活和增殖的机制的理解正在不断扩展，并且越来越多的证据表明它们对心肌细胞功能具有直接和间接的影响。在这篇综述中，我们重点关注成纤维细胞向肌成纤维细胞转化的重要性以及心肌成纤维细胞与心肌细胞之间的相互作用。我们还考虑了目前用于探索这些问题的模型的使用。
