参松养心对离体兔肺静脉心肌细胞动作电位及某些电流通道的影响
[Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes].
作者信息
Shi Liang, Yang Xin-Chun, Liu Xiu-Lan, Zong Min, Wu Yi-Ling
机构信息
Heart Center, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2009 Aug 11;89(30):2142-6.
OBJECTIVE
To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation.
METHODS
Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique.
RESULTS
ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P < 0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner.
CONCLUSION
ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels.
目的
研究参松养心对离体兔肺静脉心肌细胞动作电位及某些电流通道的影响，阐明其治疗心房颤动的可能机制。
方法
采用全细胞膜片钳技术记录动作电位以及L型钙通道电流（I(Ca-L)）、瞬时外向钾电流（I(K1)）和内向整流钾电流（I(To)）。
结果
参松养心显著延长动作电位时程（APD），在浓度为5mg/ml时，APD90从（187±49）ms增大到（286±76）ms，在浓度为10mg/dl时增大到（312±82）ms（P<0.05）。它还以浓度依赖的方式抑制I(Ca-L)、I(K1)和Iro电流。
结论
参松养心可通过作用于多个电流通道来治疗心房颤动。
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