使用三维扫频源光相干断层扫描术活体早期检测烟雾诱导的气道损伤。
In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography.
出版信息
J Biomed Opt. 2009 Nov-Dec;14(6):060503. doi: 10.1117/1.3268775.
Abstract
We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on the comprehensive 3-D volumetric data.
摘要
我们报告了快速、高分辨率、三维扫频光学相干断层扫描（SSOCT）在兔模型中检测吸入烟雾暴露后早期气道损伤变化的可行性。SSOCT 系统使用基于微机电系统（MEMS）电机的内窥镜进行三维螺旋扫描。通过采用并行计算技术，实现了 20 帧/秒的实时 2-D 数据处理和图像显示。通过图像处理算法重建纵向图像，以消除通风和脉搏引起的运动伪影。还基于全面的三维容积数据，对气管气道厚度以及沿气管圆周的厚度分布进行定量分析。
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