IEEE Trans Biomed Eng. 2021 Aug;68(8):2360-2367. doi: 10.1109/TBME.2020.3037288. Epub 2021 Jul 16.
Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.
需要定量方法来评估吸入（烧伤）损伤的严重程度，以辅助治疗决策。我们假设，根据气道壁顺应性的差异来评估损伤的严重程度是可行的。在这里，我们展示了一种定制的、内镜式的解剖光学相干弹性成像（aOCE）系统用于测量气道壁顺应性。该方法首先使用气道模型进行验证，然后在不同程度吸入（蒸汽）损伤的离体猪气管上进行。发现 aOCE 衍生的顺应性与蒸汽损伤的严重程度呈负相关，并且气道特性的空间分辨顺应性图显示出区域异质性。
