Department of Neuroscience, University Medical Center Groningen, BCN Neuroimaging Center, University of Groningen, The Netherlands.
Biol Psychiatry. 2010 May 15;67(10):912-8. doi: 10.1016/j.biopsych.2009.11.017. Epub 2010 Jan 8.
Schizophrenia has been conceptualized as a disorder of integration of neural activity across distributed networks. However, the relationship between specific symptom dimensions and patterns of functional connectivity remains unclear. The current study aimed to investigate the relationship between auditory-verbal hallucinations (AVH), a particularly prevalent and clinically relevant symptom in schizophrenia, and functional connectivity of the temporo-parietal junction (TPJ).
Resting state functional magnetic resonance imaging scans were obtained from 27 schizophrenia patients with AVH and 27 matched control subjects. We calculated correlations reflecting functional connectivity between a priori defined regions-of-interest and the bilateral TPJ seed regions, comprising the neural network involved in inner speech processes and AVH.
Compared with healthy control subjects, schizophrenia patients showed reduced functional connectivity between left TPJ and the right homotope of Broca. Within the patient group, more severe AVH were associated with reduced neural coupling between left TPJ and bilateral anterior cingulate as well as the bilateral amygdala.
In schizophrenia patients with chronic hallucinations, the left TPJ-a critical node in the speech perception/AVH network-shows reduced functional connectivity with brain areas involved in the attribution of agency, self-referent processing, and attentional control.
精神分裂症被认为是一种跨分布式网络的神经活动整合障碍。然而，特定症状维度与功能连接模式之间的关系仍不清楚。本研究旨在探讨听觉幻觉（AVH），一种在精神分裂症中特别普遍和临床相关的症状，与颞顶联合区（TPJ）功能连接之间的关系。
对 27 名有 AVH 的精神分裂症患者和 27 名匹配的对照受试者进行静息状态功能磁共振成像扫描。我们计算了反映前定义的感兴趣区域与双侧 TPJ 种子区域之间功能连接的相关性，包括涉及内言语过程和 AVH 的神经网络。
与健康对照组相比，精神分裂症患者左 TPJ 与 Broca 右侧同型部位之间的功能连接减少。在患者组中，更严重的 AVH 与左 TPJ 与双侧前扣带回以及双侧杏仁核之间的神经耦合减少有关。
在患有慢性幻觉的精神分裂症患者中，左 TPJ 作为言语感知/AVH 网络中的关键节点，与涉及归因、自我参照处理和注意力控制的大脑区域的功能连接减少。
