Shearer Hallee, Eilbott Jeffrey, Vila-Rodriguez Fidel, Noble Stephanie, Xu Ting, Vanderwal Tamara
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Imaging Neurosci (Camb). 2025 Jan 2;3. doi: 10.1162/imag_a_00411. eCollection 2025.
Functional connectivity (FC) has shown promising utility in the field of precision psychiatry. However, to translate from research to clinical use, FC reliability and sensitivity to individual differences still require improvement. Movie watching as an acquisition state offers advantages at the whole-brain level that align with the requirements of FC for individualized measures. However, it is unclear whether these advantages hold in specific brain regions important for precision psychiatry. Here, we compared univariate and multivariate reliability-based measures of movie-watching and resting-state FC data in three psychiatrically relevant brain regions. We found that the reliability of movie-watching FC was comparable with resting-state FC in the dorsolateral prefrontal cortex and presupplementary motor area, and movie-watching FC was more discriminable than resting-state FC in the temporoparietal junction. Rest had higher reliabilities at lower data amounts (e.g., under 5 minutes of scan time). We then expanded this approach to all brain regions and showed that for image intraclass correlation coefficients (I2C2), no parcels were significantly different between movie and rest. For discriminability, 25% (94/379) of parcels were better for movie than for rest, and zero parcels were better for rest. For fingerprinting, 59 parcels were better for movie (mainly in visual and temporal regions, mean improvement in accuracy = 23%) and 4 parcels were better for rest. For researchers interested in cross-state differences in FC reliability, we provide an interactive visualization tool that displays the results for all measures and for all regions in both movie and rest. These findings suggest that movie watching as an acquisition state-even when using different movies across scans-may provide a useful alternative to resting state in research studies that require optimization of FC discriminability.
功能连接性（FC）在精准精神病学领域已显示出有前景的效用。然而，要从研究转化为临床应用，FC的可靠性以及对个体差异的敏感性仍需改进。看电影作为一种采集状态，在全脑水平上具有与FC对个体化测量的要求相符的优势。然而，尚不清楚这些优势在对精准精神病学重要的特定脑区是否成立。在此，我们比较了三个与精神病学相关的脑区中基于单变量和多变量可靠性的看电影和静息态FC数据测量方法。我们发现，在背外侧前额叶皮层和辅助运动前区，看电影FC的可靠性与静息态FC相当，且在颞顶联合区，看电影FC比静息态FC更具区分性。在数据量较低时（例如扫描时间不足5分钟），静息态具有更高的可靠性。然后，我们将此方法扩展到所有脑区，结果显示，对于图像组内相关系数（I2C2），看电影和静息态之间没有显著差异。在区分性方面，25%（94/379）的脑区看电影时表现优于静息态，而静息态没有脑区表现更好。在指纹识别方面，59个脑区看电影时表现更好（主要在视觉和颞叶区域，准确率平均提高 = 23%），4个脑区静息态时表现更好。对于对FC可靠性的跨状态差异感兴趣的研究人员，我们提供了一个交互式可视化工具，可显示电影和静息态下所有测量方法和所有脑区的结果。这些发现表明，看电影作为一种采集状态——即使在不同扫描中使用不同电影——在需要优化FC区分性的研究中，可能为静息态提供一个有用的替代方案。
