Institute of Psychiatry, King's College London, London, United Kingdom.
Biol Psychiatry. 2010 Apr 15;67(8):793-5. doi: 10.1016/j.biopsych.2009.11.023. Epub 2010 Jan 8.
Craving or the "urge to consume" is a characteristic of bulimic eating disorders and addictions. Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is associated with craving. We investigated whether stimulation of the DLPFC reduces food craving in people with a bulimic-type eating disorder.
Thirty-eight people with bulimic-type eating disorders were randomly allocated to receive one session of real or sham high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC in a double-blind procedure. Outcome measures included self-reported food craving immediately after the stimulation session and frequency of bingeing over a 24-hour follow-up period.
Compared with sham control, real rTMS was associated with decreased self-reported urge to eat and fewer binge-eating episodes over the 24 hours following stimulation.
High-frequency rTMS of the left DLPFC lowers cue-induced food cravings in people with a bulimic eating disorder and may reduce binge eating. These results provide a rationale for exploring rTMS as a treatment for bulimic eating disorders.
渴望或“进食欲望”是暴食症和成瘾的特征。背外侧前额叶皮层（DLPFC）功能障碍与渴望有关。我们研究了刺激 DLPFC 是否会减少暴食症患者的食物渴望。
38 名暴食症患者被随机分配在双盲程序中接受一次左 DLPFC 的真实或假的高频重复经颅磁刺激（rTMS）。主要结局包括刺激后即刻的自我报告的食物渴望以及 24 小时随访期间暴食的频率。
与假刺激相比，真 rTMS 与刺激后 24 小时内自我报告的进食欲望降低和暴食发作次数减少相关。
左 DLPFC 的高频 rTMS 降低了暴食症患者对线索诱导的食物渴望，并可能减少暴食。这些结果为探索 rTMS 作为暴食症的治疗方法提供了依据。
