Gay Aurelia, Jaussent Isabelle, Sigaud Torrance, Billard Stephane, Attal Jerome, Seneque Maude, Galusca Bogdan, Van Den Eynde Frederique, Massoubre Catherine, Courtet Philippe, Guillaume Sebastien
University Department of Psychiatry and Addictology, North Hospital, CHU St-Etienne, St Etienne, France.
TAPE Laboratory, EA7423, Jean Monnet University, Saint Etienne, France.
Eur Eat Disord Rev. 2016 Nov;24(6):474-481. doi: 10.1002/erv.2475. Epub 2016 Sep 15.
Studies suggest that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS programme targeting the left DLPFC. Forty-seven women with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent 10 rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in bingeing and purging symptoms was noted after the programme. rTMS was well tolerated. This suggests that 10 sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
研究表明，刺激左侧背外侧前额叶皮层（DLPFC）可减少贪食症患者对食物的渴望，但缺乏支持重复经颅磁刺激（rTMS）作为一种治疗工具的证据。我们研究了针对左侧DLPFC的辅助高频rTMS方案的安全性和治疗效果。47名神经性贪食症女性被随机分为真刺激组或假刺激组。真刺激组接受10次rTMS治疗，每次由20串5秒的刺激组成，串间间隔55秒，频率为10赫兹。主要结局是刺激结束后15天内的暴饮暴食发作次数。总体而言，该方案实施后，暴饮暴食和清除症状未出现显著改善。rTMS耐受性良好。这表明对左侧DLPFC进行10次高频rTMS治疗并不比安慰剂更有益。未来的研究应考虑方法学问题以及其他靶点。版权所有©2016约翰·威利父子有限公司和饮食失调协会。
